ZNF596
ZNF596 (zinc finger protein 596) is a nuclear member of the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation, and is predicted to act as a sequence-specific DNA-binding transcription factor. Browse Assay Genie's current range of ZNF596 research reagents below, or read on for the biology behind the target.
ZNF596 is a zinc finger protein that, according to UniProt, may be involved in transcriptional regulation. The NCBI Gene summary, provided by the Alliance of Genome Resources, describes it as predicted to enable DNA-binding transcription factor activity that is specific to RNA polymerase II. It is also predicted to bind sequence-specific DNA in transcription regulatory regions and to take part in the regulation of transcription by RNA polymerase II. These functions are predictions and have not been established experimentally in the sources used here.
The ZNF596 protein belongs to the krueppel C2H2-type zinc-finger protein family. The HGNC places the gene in two groups: the C2H2-type zinc fingers and the KRAB domain containing proteins. Both groups are typical of proteins that bind DNA through zinc finger motifs and are linked to transcriptional control. UniProt lists the subcellular location as the nucleus, and the NCBI summary also predicts activity in the nucleus. This matches a role in regulating gene expression.
The ZNF596 gene has the approved HGNC name zinc finger protein 596, and no alternative symbols or previous names are recorded. Because the available annotation is limited and mostly predicted, ZNF596 is still a poorly characterised member of a large transcription factor family. Researchers studying it will often compare it with other KRAB zinc finger proteins to place it in the wider regulatory network.
ZNF596 may be involved in transcriptional regulation and is predicted to regulate transcription by RNA polymerase II.
ZNF596 is predicted to bind sequence-specific DNA in transcription regulatory regions, making it a candidate for DNA-binding analysis.
UniProt lists ZNF596 as nuclear, and the NCBI summary predicts activity in the nucleus, so localisation studies are relevant.
ZNF596 belongs to the krueppel C2H2-type family and the KRAB domain containing gene group, which supports comparative family studies.
UniProt states that ZNF596 may be involved in transcriptional regulation. The NCBI Gene summary predicts that it acts as a DNA-binding transcription factor specific to RNA polymerase II and binds sequence-specific DNA in regulatory regions. These roles are predicted, and the protein is localised to the nucleus.
No aliases or previous symbols are recorded for ZNF596. The approved HGNC name is zinc finger protein 596, and UniProt uses the protein name Zinc finger protein 596. Searching with the gene symbol ZNF596 is the most reliable approach.
ZNF596 belongs to the krueppel C2H2-type zinc-finger protein family. HGNC classes it within the C2H2-type zinc fingers and the KRAB domain containing gene groups. Orthologs in mouse and rat are not given in the data used here, so check the datasheet of any product for its validated reactivity.
Other zinc finger proteins and predicted transcription factors that may be of interest alongside ZNF596.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TC21; product specifications from Assay Genie datasheets.