TAL1
TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor), also known as SCL, bHLHa17 and TCL5, is a nuclear basic helix-loop-helix transcription factor. It acts as a positive regulator of erythroid differentiation and is implicated in haemopoietic malignancies. Browse Assay Genie's current range of TAL1 research reagents below, or read on for the biology behind the target.
TAL1 is a DNA-binding transcription factor that recognises E-box sequences and can also bind histone deacetylases. It is found in the nucleus, where it is located in chromatin and nucleoplasm and forms part of transcription regulator complexes. UniProt annotates it as a positive regulator of erythroid differentiation that may play an important role in haemopoietic differentiation more broadly.
The NCBI Gene summary links TAL1 to several cellular processes, including myeloid cell differentiation, positive regulation of erythrocyte differentiation and positive regulation of cellular component organisation. Together these annotations place the TAL1 protein at the centre of blood-cell lineage control. The mouse ortholog is Tal1.
The TAL1 gene belongs to the HGNC group of basic helix-loop-helix proteins, which explains the alias bHLHa17. Its other aliases, SCL and TCL5, and its previous name, T-cell acute lymphocytic leukaemia 1, reflect its association with disease. TAL1 is implicated in acute lymphoblastic leukaemia and in the genesis of haemopoietic malignancies, so it is studied both as a developmental regulator and as a leukaemia-associated factor.
TAL1 may play an important role in haemopoietic differentiation, making it a key factor for studying how blood cell lineages are specified.
TAL1 is a positive regulator of erythroid differentiation and of erythrocyte differentiation, so it is relevant to research on red blood cell development.
TAL1 is implicated in acute lymphoblastic leukaemia and in the genesis of haemopoietic malignancies, which supports work on disease mechanisms.
As an E-box binding bHLH factor that associates with histone deacetylases and transcription regulator complexes, TAL1 is a model for studying gene control.
TAL1 is a nuclear DNA-binding transcription factor that binds E-box elements. UniProt describes it as a positive regulator of erythroid differentiation that may have an important role in haemopoietic differentiation. NCBI also lists involvement in myeloid cell differentiation.
TAL1 is also called SCL, bHLHa17 and TCL5. UniProt names it T-cell acute lymphocytic leukaemia protein 1, and the previous HGNC name was T-cell acute lymphocytic leukaemia 1. The name reflects its link to leukaemia, and bHLHa17 reflects its protein family.
TAL1 is implicated in acute lymphoblastic leukaemia and in the genesis of haemopoietic malignancies. The mouse ortholog is Tal1, so mouse models can be used to study it. Check the datasheet of any product for its validated reactivity.
Other targets with products at Assay Genie, including a gene with a similar-looking symbol.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P17542; product specifications from Assay Genie datasheets.