KIR2DL2
KIR2DL2 (killer cell immunoglobulin-like receptor 2DL2, also known as CD158B1, CD158k, cl-43 and nkat6) is a cell-membrane receptor on natural killer cells that recognises HLA-C molecules. Its engagement inhibits NK cell activity and prevents target cell lysis. Browse Assay Genie's current range of KIR2DL2 research reagents below, or read on for the biology behind the target.
KIR2DL2 is a receptor on natural killer (NK) cells for the HLA-Cw1, Cw3, Cw7 and Cw8 allotypes. When it binds these HLA class I ligands, it inhibits the activity of the NK cell and so prevents cell lysis. The protein belongs to the immunoglobulin superfamily and is found at the cell membrane.
The KIR2DL2 gene is one of the killer cell immunoglobulin-like receptor (KIR) genes, a polymorphic and highly homologous cluster within the leukocyte receptor complex on chromosome 19q13.4. KIRs are transmembrane glycoproteins expressed by NK cells and subsets of T cells. They are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether the cytoplasmic domain is long (L) or short (S). The name KIR2DL2 reflects this: two Ig domains and a long cytoplasmic tail. The gene content of the KIR cluster varies among haplotypes, although a few framework genes are present in all of them.
KIR proteins with a long cytoplasmic domain, such as KIR2DL2, transduce inhibitory signals after ligand binding through an immune tyrosine-based inhibitory motif (ITIM). Short-tailed KIRs lack the ITIM and instead associate with the TYRO protein tyrosine kinase binding protein to transmit activating signals. Because the ligands of several KIRs are subsets of HLA class I molecules, KIR proteins are thought to play an important role in regulating the immune response. KIR2DL2 is also listed in the CD molecules gene group as CD158b1, and its previous name was killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2.
KIR2DL2 is an inhibitory receptor that restrains NK cell activity, making it relevant to studies of how NK cells are regulated.
It recognises HLA-Cw1, Cw3, Cw7 and Cw8 allotypes, which makes it a model for receptor-ligand interactions with HLA-C.
KIR proteins are thought to play an important role in regulating the immune response through their interactions with HLA class I molecules.
KIR genes are polymorphic and their content varies among haplotypes, so KIR2DL2 is relevant to studies of KIR gene diversity.
KIR2DL2 is a receptor on natural killer cells for HLA-Cw1, Cw3, Cw7 and Cw8 allotypes. Ligand binding inhibits NK cell activity and thereby prevents cell lysis. Its long cytoplasmic tail carries an ITIM, which transduces the inhibitory signal.
KIR2DL2 is also known as CD158B1, CD158k, cl-43 and nkat6. The UniProt name is killer cell immunoglobulin-like receptor 2DL2. The HGNC name describes its structure: two Ig domains and a long cytoplasmic tail. The name 'two domains, long cytoplasmic tail, 2' was used previously.
KIR2DL2 belongs to the polymorphic KIR gene cluster in the leukocyte receptor complex on chromosome 19q13.4, and the family belongs to the immunoglobulin superfamily. Gene content varies among haplotypes. No mouse or rat ortholog is given in the data supplied; check the datasheet of any product for its validated reactivity.
Other killer cell immunoglobulin-like receptors and NK cell receptors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P43627; product specifications from Assay Genie datasheets.