CLMP
CLMP (CXADR like cell adhesion molecule, also known as ASAM, ACAM and FLJ22415) is a type I transmembrane protein found at junctional complexes between endothelial and epithelial cells. It may contribute to cell-cell adhesion and is required for normal small intestine development. Browse Assay Genie's current range of CLMP research reagents below, or read on for the biology behind the target.
CLMP is a membrane protein that may be involved in cell-cell adhesion. According to the NCBI Gene summary, it is a type I transmembrane protein localised to junctional complexes between endothelial and epithelial cells. UniProt records its subcellular location as the tight junction and the cell membrane, which fits a role in maintaining contacts between neighbouring cells. Beyond adhesion, CLMP may play a role in adipocyte differentiation and in the development of obesity, and it is required for normal small intestine development.
The human CLMP gene encodes the protein CXADR-like membrane protein. HGNC places it in the V-set domain containing, I-set domain containing and IgCAM CXADR-related subfamily groups, so it belongs to the immunoglobulin-like cell adhesion molecule class. Mouse and rat both have a Clmp ortholog, which allows the biology of this protein to be studied in rodent models. Researchers who work with a CLMP antibody, CLMP ELISA kit or recombinant CLMP protein will usually be examining junctional biology, adipose tissue or gut development.
The gene has gone by several names. It was previously described as CXADR like membrane protein, and the aliases ASAM, ACAM and FLJ22415 appear in the literature and in databases. In white adipose tissue, CLMP expression is implicated in adipocyte maturation and in the development of obesity. The gene is also essential for normal intestinal development, and mutations in it are associated with congenital short bowel syndrome. This link makes CLMP a useful target for studying how adhesion proteins shape the developing gut.
CLMP may be involved in cell-cell adhesion and sits at junctional complexes between endothelial and epithelial cells.
CLMP is required for normal small intestine development, and mutations in its gene are associated with congenital short bowel syndrome.
CLMP expression in white adipose tissue is implicated in adipocyte maturation and the development of obesity.
UniProt places CLMP at the tight junction and cell membrane, making it relevant to studies of junctional organisation.
CLMP may be involved in cell-cell adhesion and is localised to junctions between endothelial and epithelial cells. It may also play a role in adipocyte differentiation and the development of obesity, and it is required for normal small intestine development.
CLMP stands for CXADR like cell adhesion molecule. UniProt lists the protein as CXADR-like membrane protein, and the aliases ASAM, ACAM and FLJ22415 are also used. The previous HGNC name was CXADR like membrane protein.
Mutations in the CLMP gene are associated with congenital short bowel syndrome. Mouse and rat each have a Clmp ortholog, so rodent models can be used for study; check the datasheet of any product for its validated reactivity.
Other immunoglobulin-like adhesion molecules and junctional proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H6B4; product specifications from Assay Genie datasheets.