TNNC2
TNNC2 (troponin C2, fast skeletal type) is the Tn-C subunit of the troponin complex, a central regulator of striated muscle contraction. It binds calcium and relieves the inhibitory action of troponin on actin filaments; it is also known as FAP85 and CFAP85. Browse Assay Genie's current range of TNNC2 research reagents below, or read on for the biology behind the target.
Troponin is the central regulatory protein complex of striated muscle contraction, and TNNC2 encodes one of its three components. The complex is made up of Tn-I, the inhibitor of actomyosin ATPase, Tn-T, which contains the binding site for tropomyosin, and Tn-C. Tn-C is the calcium-binding subunit. When calcium binds to Tn-C, the inhibitory action of the troponin complex on actin filaments is abolished, which allows contraction to proceed. The protein encoded by the TNNC2 gene is the Tn-C subunit, and UniProt records it as troponin C, skeletal muscle.
The TNNC2 protein belongs to the troponin C family. HGNC places it in several gene groups: EF-hand domain containing, troponin complex subunits, and cilia and flagella associated. The last group is reflected in the aliases FAP85 and CFAP85. The mouse ortholog is Tnnc2. The source records used here do not annotate a subcellular location for the protein.
The approved HGNC name, troponin C2, fast skeletal type, was previously given as troponin C type 2 (fast). This distinguishes it from TNNC1, the other troponin C gene. Researchers studying striated muscle regulation use TNNC2 to examine how calcium binding by Tn-C is coupled to the other troponin subunits and to the thin filament. Work on troponin signalling in muscle contraction often compares the Tn-C, Tn-I and Tn-T components together.
TNNC2 encodes Tn-C, the calcium-binding subunit of troponin, a key regulator of striated muscle contraction.
Calcium binding to Tn-C abolishes the inhibitory action of the troponin complex on actin filaments.
Tn-C works with Tn-I, which inhibits actomyosin ATPase, and Tn-T, which binds tropomyosin.
TNNC2 is an EF-hand domain containing member of the troponin C family, useful for comparing calcium-binding proteins.
TNNC2 encodes Tn-C, the calcium-binding subunit of troponin, the central regulatory complex of striated muscle contraction. Binding of calcium to Tn-C abolishes the inhibitory action of troponin on actin filaments. Tn-I inhibits actomyosin ATPase, and Tn-T contains the tropomyosin-binding site.
The HGNC name is troponin C2, fast skeletal type, previously troponin C type 2 (fast). UniProt calls the protein troponin C, skeletal muscle. Aliases include FAP85 and CFAP85, reflecting its HGNC membership of the cilia and flagella associated gene group.
The mouse ortholog is Tnnc2. A rat ortholog is not given in the data supplied here. TNNC2 belongs to the troponin C family, alongside TNNC1. Check the datasheet of any product for its validated reactivity.
Other troponin C family members and muscle regulatory proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P02585; product specifications from Assay Genie datasheets.