There are no products listed under this category.
CLIP2
CLIP2, the CAP-Gly domain containing linker protein 2 (also known as CLIP-115, CYLN2 and WSCR4), is a cytoplasmic linker protein that associates with microtubules. It appears to connect microtubules to a specialised neuronal organelle, the dendritic lamellar body. Browse Assay Genie's current range of CLIP2 research reagents below, or read on for the biology behind the target.
CLIP2 belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. The CLIP2 protein has been found to associate with both microtubules and the dendritic lamellar body (DLB), a membranous organelle found mainly in bulbous dendritic appendages of neurons that are connected by dendrodendritic gap junctions.
On this basis, CLIP2 seems to link microtubules to the DLB and may operate in the control of brain-specific organelle translocations. The protein is found in the cytoplasm and the cytoskeleton. Researchers studying the CLIP2 gene and protein are therefore often interested in neuronal cell biology, microtubule-based transport and the way organelles are positioned within specialised cell structures.
The CLIP2 gene lies at 7q11.23 and is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by deletion of contiguous genes in this region. This is reflected in older names and symbols such as Williams-Beuren syndrome chromosome region 3 (WBSCR3) and WSCR4. Other aliases include cytoplasmic linker 2, CLIP-115 and KIAA0291. Alternative splicing of the gene generates two transcript variants. Mouse and rat both carry a Clip2 ortholog. CLIP2 is closely related to CLIP1, another member of the cytoplasmic linker family.
CLIP2 is proposed to mediate the interaction between specific membranous organelles and microtubules, making it a subject for studies of cytoskeletal linkage.
CLIP2 associates with the dendritic lamellar body, an organelle found in neuronal dendritic appendages joined by dendrodendritic gap junctions.
CLIP2 may operate in the control of brain-specific organelle translocations, an area of interest for intracellular transport research.
The CLIP2 gene is hemizygously deleted in Williams syndrome, so it is studied among the contiguous genes at 7q11.23.
CLIP2 seems to link microtubules to the dendritic lamellar body, a membranous organelle in bulbous dendritic appendages of neurons. It may operate in the control of brain-specific organelle translocations. It belongs to the cytoplasmic linker proteins, proposed to mediate organelle-microtubule interactions.
CLIP2 is also called CLIP-115, CLIP, CYLN2, KIAA0291, WSCR3, WSCR4, WBSCR3 and WBSCR4. Earlier names include cytoplasmic linker 2 and Williams-Beuren syndrome chromosome region 3. Alternative splicing produces two transcript variants.
The CLIP2 gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by deletion of contiguous genes at 7q11.23. Mouse and rat each have a Clip2 ortholog; check the datasheet of any product for its validated reactivity.
Another cytoplasmic linker protein that works at the microtubule interface, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UDT6; product specifications from Assay Genie datasheets.
There are no products listed under this category.