ONECUT1
ONECUT1 (one cut homeobox 1) is a nuclear transcription factor of the CUT homeobox family that activates gene promoters and is important for liver gene transcription. It is also known as hepatocyte nuclear factor 6, HNF-6, HNF6 and HNF6A. Browse Assay Genie's current range of ONECUT1 research reagents below, or read on for the biology behind the target.
ONECUT1 acts as a transcriptional activator. The protein binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters, including those of HNF3B and TTR, and is important for the transcription of liver genes. Its expression is enriched in the liver, where it stimulates transcription of liver-expressed genes and antagonises glucocorticoid-stimulated gene transcription.
The protein, also called hepatocyte nuclear factor 6 (HNF-6, HNF6 or HNF6A), localises to the nucleus and belongs to the CUT homeobox family. The ONECUT1 gene sits in the HGNC group of CUT class homeoboxes and pseudogenes. Mouse and rat both carry an ortholog named Onecut1, which allows the factor to be studied in rodent models. Alternative splicing of the gene results in multiple transcript variants.
HGNC previously listed the gene as one cut domain, family member 1. According to the NCBI Gene summary, ONECUT1 may influence a variety of cellular processes, including glucose metabolism and cell cycle regulation, and it may also be associated with cancer. These links make the ONECUT1 protein a useful subject for studies of hepatic gene regulation and transcriptional control.
ONECUT1 is important for liver gene transcription and is enriched in the liver, where it stimulates liver-expressed genes.
The protein antagonises glucocorticoid-stimulated gene transcription, making it relevant to studies of how transcription factors modulate hormone responses.
ONECUT1 may influence glucose metabolism and cell cycle regulation, according to the NCBI Gene summary.
The gene may be associated with cancer, so ONECUT1 is of interest in studies of transcriptional dysregulation in tumours.
ONECUT1 is a nuclear transcriptional activator. It binds a defined consensus sequence on promoters such as those of HNF3B and TTR, and is important for liver gene transcription. It also antagonises glucocorticoid-stimulated gene transcription.
The UniProt protein name is hepatocyte nuclear factor 6, with aliases HNF-6, HNF6 and HNF6A. HGNC previously named the gene one cut domain, family member 1. Alternative splicing produces multiple transcript variants.
Mouse and rat both have an ortholog named Onecut1; check the datasheet of any product for its validated reactivity. NCBI Gene notes that ONECUT1 may influence glucose metabolism and cell cycle regulation, and may be associated with cancer.
Other transcription factors and liver-enriched regulators studied alongside ONECUT1.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UBC0; product specifications from Assay Genie datasheets.