S100A5
S100A5 (S100 calcium binding protein A5, also known as S100D) is a member of the S100 family of EF-hand calcium-binding proteins. It binds calcium, zinc and copper, and is expressed in very restricted regions of the adult brain. Browse Assay Genie's current range of S100A5 research reagents below, or read on for the biology behind the target.
S100A5 is a metal-binding protein. One subunit can simultaneously bind two calcium ions, or two copper ions plus one zinc ion, and calcium and copper compete for the same binding sites. Its calcium affinity is 20- to 100-fold higher than that of the other S100 proteins studied under identical conditions. It also binds zinc and copper, and strong copper binding impairs the binding of calcium.
The S100A5 gene encodes a protein that contains two EF-hand calcium-binding motifs. It belongs to the S100 family, whose members are localised in the cytoplasm and/or nucleus of a wide range of cells. S100 proteins are involved in regulating cellular processes such as cell cycle progression and differentiation. The S100 gene cluster includes at least 13 members on chromosome 1q21. HGNC places S100A5 in the groups of S100 calcium binding proteins and EF-hand domain containing proteins. Researchers working with an S100A5 antibody, S100A5 ELISA kit or recombinant S100A5 protein should note that expression of this protein is reported in very restricted regions of the adult brain.
The gene was previously named S100 calcium-binding protein A5 and carries the alias S100D. Mouse and rat each have an S100a5 ortholog, which allows comparative work across common model species. The competition between copper and calcium at shared binding sites makes S100A5 a useful subject for studying how metal ions shape S100 protein behaviour.
S100A5 has a calcium affinity 20- to 100-fold higher than other S100 proteins studied under identical conditions, making it a notable model for EF-hand calcium binding.
S100A5 binds calcium, zinc and copper, and copper binding impairs calcium binding, so it is relevant to studies of metal competition at shared sites.
S100A5 is expressed in very restricted regions of the adult brain, which makes it of interest for mapping regional protein expression.
As one of at least 13 clustered S100 genes at 1q21, S100A5 supports comparative work on S100 roles in cell cycle progression and differentiation.
S100A5 binds calcium, zinc and copper. One subunit can bind two calcium ions, or two copper ions plus one zinc ion, and calcium and copper compete for the same sites. As an S100 family member, it belongs to a group involved in regulating cell cycle progression and differentiation.
The HGNC symbol is S100A5 and the approved name is S100 calcium binding protein A5. The alias S100D is also used, and UniProt lists the protein as Protein S100-A5. The previous name was S100 calcium-binding protein A5.
Yes. Mouse and rat each have an S100a5 ortholog, so the gene can be studied in common rodent models. Cross-species reactivity differs between reagents, so check the datasheet of any product for its validated reactivity.
Other S100 family calcium-binding proteins that share EF-hand motifs and the 1q21 gene cluster with S100A5.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P33763; product specifications from Assay Genie datasheets.