VWA5A
VWA5A (von Willebrand factor A domain containing 5A) is a human protein proposed to act as a tumour suppressor. It is also known as BCSC-1 and LOH11CR2A, the latter reflecting its original identification in a region of chromosome 11 affected by loss of heterozygosity. Browse Assay Genie's current range of VWA5A research reagents below, or read on for the biology behind the target.
VWA5A is annotated in UniProt as a protein that may play a role in tumorigenesis as a tumour suppressor. The annotation suggests that altered expression of the VWA5A protein, together with disruption of the molecular pathway in which it is involved, may contribute directly to tumorigenesis or modify it. The specific biochemical mechanism has not been defined in the sources used for this page, so the protein is best described as a candidate tumour suppressor rather than a characterised enzyme or signalling component.
Human VWA5A is a protein of 786 amino acids encoded by the VWA5A gene, and its name reflects the von Willebrand factor A domain it contains. The NCBI Gene summary, provided by the Alliance of Genome Resources, places the protein in the nucleoplasm. Mouse and rat both have an ortholog named Vwa5a, which allows the target to be studied in common rodent models.
The gene has been known under several names. HGNC lists BCSC-1 and LOH11CR2A as aliases, and the previous gene name was loss of heterozygosity, 11, chromosomal region 2, gene A. This history ties the locus to studies of chromosomal loss in tumours. Researchers investigating the VWA5A gene or protein typically do so in the context of cancer biology, where expression changes are the main point of interest.
VWA5A is proposed to act as a tumour suppressor, making it a candidate for studies of how its loss influences tumorigenesis.
Altered VWA5A expression may contribute to or modify tumorigenesis, so expression changes are a natural readout in tumour studies.
VWA5A is reported in the nucleoplasm, which is relevant to work on its subcellular distribution and nuclear function.
Mouse and rat share a Vwa5a ortholog, supporting comparative studies of the gene across mammalian species.
UniProt states that VWA5A may play a role in tumorigenesis as a tumour suppressor. Altered expression of the protein, and disruption of the molecular pathway it participates in, may contribute directly to tumorigenesis or modify it. Its precise molecular mechanism is not described in the available annotation.
VWA5A stands for von Willebrand factor A domain containing 5A. HGNC lists the aliases BCSC-1 and LOH11CR2A, and the earlier gene name was loss of heterozygosity, 11, chromosomal region 2, gene A. Older literature may use these names instead of VWA5A.
Yes. Both mouse and rat carry an ortholog named Vwa5a, so the gene is present in the main rodent models. Check the datasheet of any product for its validated reactivity before choosing a reagent for a given species.
Other von Willebrand factor A domain proteins and well-studied tumour suppressors that may be of interest alongside VWA5A.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O00534; product specifications from Assay Genie datasheets.