ELAVL2
ELAVL2 (ELAV like RNA binding protein 2, also known as HuB and HEL-N1) is an RNA-binding protein of the ELAV family that binds the 3' untranslated region of target mRNAs. It regulates gene expression post-transcriptionally and is expressed specifically in neurons. Browse Assay Genie's current range of ELAVL2 research reagents below, or read on for the biology behind the target.
ELAVL2 is an RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs. ELAVL RNA-binding proteins recognise AU-rich elements in the 3' UTRs of gene transcripts and thereby regulate gene expression post-transcriptionally. ELAVL2 appears to recognise a GAAA motif, and it is reported to bind several 3' UTRs, including its own and those of FOS, ID and POU5F1.
The ELAVL2 gene is one of four members of the human ELAV like RNA binding protein gene family (ELAVL1-4). The protein belongs to the RRM elav family. Like ELAVL3 and ELAVL4, ELAVL2 is expressed specifically in neurons, whereas ELAVL1 is more broadly studied. ELAVL2 primarily localises to the cytoplasm, and it also forms a cytosolic complex with ELAVL1, a protein that is normally localised to the nucleus. Alternative splicing of the gene results in multiple transcript variants that encode distinct protein isoforms.
HGNC classifies the gene within the RNA binding motif containing group and the ELAV like RNA binding protein family. Earlier names include ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) and ELAV like neuron-specific RNA binding protein 2, reflecting the Drosophila ELAV protein after which the family was named. Mouse and rat both carry an Elavl2 ortholog, which makes rodent models a practical route for studying its function.
ELAVL2 binds AU-rich elements in 3' UTRs, making it a useful subject for studying how mRNA-binding proteins control gene expression after transcription.
Expression restricted to neurons makes ELAVL2 relevant to work on neuron-specific RNA-binding proteins and the ELAVL3 and ELAVL4 paralogues.
Reported binding to the 3' UTRs of FOS, ID, POU5F1 and its own transcript provides defined targets for studying RNA-protein interactions.
ELAVL2 forms a cytosolic complex with the normally nuclear ELAVL1, offering a route into how family members interact and are distributed within the cell.
ELAVL2 is an RNA-binding protein that binds the 3' untranslated region of target mRNAs, apparently recognising a GAAA motif. By recognising AU-rich elements it regulates gene expression post-transcriptionally. Reported targets include its own 3'UTR and those of FOS, ID and POU5F1.
ELAVL2 is also called HuB and HEL-N1, and earlier names include ELAV-like 2 (Hu antigen B) and ELAV like neuron-specific RNA binding protein 2. Alternative splicing of the gene gives multiple transcript variants that encode distinct protein isoforms.
Mouse and rat both have an Elavl2 ortholog; check the datasheet of any product for its validated reactivity. ELAVL2 is one of four human ELAVL proteins (ELAVL1-4). It is neuron-specific and forms a cytosolic complex with ELAVL1, which is normally nuclear.
ELAVL1, the family member that forms a cytosolic complex with ELAVL2, and other RNA-binding proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q12926; product specifications from Assay Genie datasheets.