ETFB
ETFB (electron transfer flavoprotein subunit beta) is the beta subunit of a heterodimeric flavoprotein in the mitochondrial matrix. It accepts electrons from several mitochondrial dehydrogenases and passes them to the respiratory chain, supporting fatty acid oxidation and amino acid metabolism. Browse Assay Genie's current range of ETFB research reagents below, or read on for the biology behind the target.
ETFB is one subunit of the electron transfer flavoprotein (ETF), a heterodimer that collects electrons from several mitochondrial dehydrogenases. These include the acyl-CoA dehydrogenases, glutaryl-CoA dehydrogenase and sarcosine dehydrogenase. The ETF then transfers the electrons to the main mitochondrial respiratory chain through ETF-ubiquinone oxidoreductase. In this way it links primary flavoprotein dehydrogenases to the membrane-bound electron transfer machinery, and it is required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism.
The ETFB protein sits in the mitochondrial matrix and belongs to the ETF beta-subunit/FixA family. UniProt records that it binds an AMP molecule, which probably has a purely structural role. HGNC places the ETFB gene in the flavoproteins group. The mouse and rat orthologues are both named Etfb. NCBI Gene reports that alternatively spliced transcript variants have been found for this gene.
The gene was previously named electron-transfer-flavoprotein, beta polypeptide. Deficiencies of the gene have been implicated in type II glutaricaciduria, which makes ETFB a relevant subject for studies of inherited disorders of mitochondrial fatty acid and amino acid catabolism. Researchers working on ETFB commonly study it alongside its partner subunit and the dehydrogenases that feed electrons into the ETF.
ETFB is required for normal mitochondrial fatty acid oxidation, receiving electrons from acyl-CoA dehydrogenases during fatty acid breakdown.
The ETF accepts electrons from dehydrogenases such as glutaryl-CoA and sarcosine dehydrogenase, supporting normal amino acid metabolism.
ETFB-containing ETF passes electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase, linking matrix dehydrogenases to ubiquinone.
Deficiencies of the ETFB gene have been implicated in type II glutaricaciduria, a focus for mitochondrial disease research.
ETFB is a subunit of the heterodimeric electron transfer flavoprotein. The complex accepts electrons from mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, and transfers them to the respiratory chain via ETF-ubiquinone oxidoreductase. This supports fatty acid oxidation and amino acid metabolism.
HGNC lists the full name as electron transfer flavoprotein subunit beta, with the previous name electron-transfer-flavoprotein, beta polypeptide. No other aliases are recorded. NCBI Gene notes that alternatively spliced transcript variants have been found for the gene.
Deficiencies of the ETFB gene have been implicated in type II glutaricaciduria. Orthologues named Etfb exist in mouse and rat, so rodent models can be used to study it. Check the datasheet of any product for its validated reactivity.
Other electron transfer flavoproteins, acyl-CoA dehydrogenases and mitochondrial metabolism targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P38117; product specifications from Assay Genie datasheets.