EGR4
EGR4 (early growth response 4) is a nuclear C2H2-type zinc-finger transcriptional regulator, also known as NGFI-C or PAT133. It binds a defined GC-rich DNA sequence and activates genes needed for mitogenesis and differentiation. Browse Assay Genie's current range of EGR4 research reagents below, or read on for the biology behind the target.
EGR4 is a sequence-specific transcription factor. It recognises and binds the DNA sequence 5'-GCGGGGGCG-3' (GSG) and activates transcription of target genes whose products are required for mitogenesis and differentiation. NCBI Gene annotation describes it as enabling DNA-binding transcription activator activity specific to RNA polymerase II, with sequence-specific double-stranded DNA binding, and as being involved in positive regulation of transcription by RNA polymerase II.
The EGR4 gene encodes Early growth response protein 4, which belongs to the EGR C2H2-type zinc-finger protein family. HGNC places it in the zinc fingers C2H2-type group and the early growth response family. The protein is located in the nucleus and is predicted to be associated with chromatin, consistent with its role in regulating gene expression. Mouse and rat orthologs are both named Egr4, which allows comparative work across common model species.
The protein is also known as NGFI-C, and PAT133 is a further alias. Researchers studying EGR4 often consider it alongside other family members such as EGR1, EGR2 and EGR3, which share the same zinc-finger family classification. An EGR4 antibody or EGR4 ELISA kit can be used to examine expression of the EGR4 protein in studies of transcriptional control of growth and differentiation.
EGR4 binds the GSG sequence and activates RNA polymerase II-dependent transcription, making it a model for sequence-specific zinc-finger regulation.
EGR4 activates target genes whose products are required for mitogenesis, linking it to studies of cell growth control.
Genes activated by EGR4 are required for differentiation, so the protein is relevant to studies of how cells commit to specialised fates.
As a member of the EGR C2H2-type zinc-finger family, EGR4 supports comparative studies with EGR1, EGR2 and EGR3.
EGR4 is a transcriptional regulator. It recognises and binds the DNA sequence 5'-GCGGGGGCG-3' and activates transcription of target genes whose products are required for mitogenesis and differentiation. It acts in the nucleus and is predicted to associate with chromatin.
The HGNC full name is early growth response 4, and the UniProt protein name is Early growth response protein 4. Aliases include NGFI-C and PAT133. HGNC lists no previous names. Check these aliases when searching literature or databases for the EGR4 gene.
Yes. Both mouse and rat have an ortholog named Egr4. EGR4 also belongs to the EGR C2H2-type zinc-finger family alongside EGR1, EGR2 and EGR3; check the datasheet of any product for its validated reactivity.
Other early growth response family transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q05215; product specifications from Assay Genie datasheets.