GPD2
GPD2 (glycerol-3-phosphate dehydrogenase 2) is a calcium-responsive, FAD-dependent enzyme of the inner mitochondrial membrane. It converts glycerol-3-phosphate to dihydroxyacetone phosphate and, with GPD1, forms the glycerol phosphate shuttle that reoxidises glycolytic NADH. Browse Assay Genie's current range of GPD2 research reagents below, or read on for the biology behind the target.
GPD2 is a mitochondrial glycerol-3-phosphate dehydrogenase that localises to the inner mitochondrial membrane. It catalyses the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Together with GPD1, the enzyme constitutes the glycerol phosphate shuttle, which reoxidises the NADH formed during glycolysis. UniProt describes it as a calcium-responsive enzyme that seems to be a key component of the pancreatic beta-cell glucose-sensing device.
The GPD2 protein belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. HGNC places the GPD2 gene in the groups of EF-hand domain containing proteins, flavoproteins and glycerol-3-phosphate dehydrogenases, which fits its calcium responsiveness and its flavin cofactor. The enzyme carries the EC number 1.1.5.3. According to the NCBI Gene summary, two transcript variants encode the same protein, so the gene gives rise to a single protein product.
The approved name, glycerol-3-phosphate dehydrogenase 2, replaced the earlier form glycerol-3-phosphate dehydrogenase 2 (mitochondrial); no other aliases or previous symbols are recorded. Orthologous genes, written Gpd2, are present in mouse and rat, so the target can be studied in common rodent models. Because GPD2 links glycolysis to the mitochondrion and is implicated in beta-cell glucose sensing, it is a useful target for work on cellular redox balance and energy metabolism.
GPD2 and GPD1 together form the shuttle that reoxidises NADH generated during glycolysis, making GPD2 a focus for studies of cytosolic-mitochondrial redox coupling.
UniProt notes that GPD2 seems to be a key component of the pancreatic beta-cell glucose-sensing device, relevant to glucose-responsive cell function.
As an FAD-dependent dehydrogenase of the inner mitochondrial membrane, GPD2 is a model for flavoprotein catalysis converting glycerol-3-phosphate to dihydroxyacetone phosphate.
GPD2 is a calcium-responsive enzyme belonging to the EF-hand domain containing group, supporting research into how calcium signals tune mitochondrial metabolism.
GPD2 is a mitochondrial enzyme that catalyses the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. With GPD1 it forms the glycerol phosphate shuttle, which reoxidises NADH produced in glycolysis. It also seems to be a key part of the beta-cell glucose-sensing device.
The full name is glycerol-3-phosphate dehydrogenase 2, and UniProt lists it as glycerol-3-phosphate dehydrogenase, mitochondrial. The earlier HGNC name added the word mitochondrial in brackets. No other aliases or previous symbols are recorded. Two transcript variants are known, and both encode the same protein.
Yes. Mouse and rat both carry an orthologous gene named Gpd2, so the enzyme can be studied in standard rodent models. Cross-reactivity depends on the individual reagent, so check the datasheet of any product for its validated reactivity.
GPD1, the partner enzyme of the glycerol phosphate shuttle, and other related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P43304; product specifications from Assay Genie datasheets.