CSNK2B
CSNK2B encodes the regulatory beta subunit of casein kinase II (CK2), a ubiquitous protein kinase involved in metabolic pathways, signal transduction, transcription, translation and replication. It is also known as casein kinase 2, beta polypeptide, Ckb1 and Ckb2. Browse Assay Genie's current range of CSNK2B research reagents below, or read on for the biology behind the target.
Casein kinase II is a ubiquitous protein kinase that regulates metabolic pathways, signal transduction, transcription, translation and replication. The enzyme is built from three subunit types, alpha, alpha prime and beta, which assemble into a tetrameric holoenzyme. The alpha and alpha prime subunits (CSNK2A1 and CSNK2A2) are catalytic, whereas the CSNK2B protein serves regulatory functions within the complex.
The CSNK2B gene encodes the beta subunit and belongs to the casein kinase 2 beta family. UniProt records the protein in the nucleus, while the NCBI Gene summary notes that the CK2 enzyme localises to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been reported for this gene. HGNC lists the approved name as casein kinase 2 beta, with the previous name casein kinase 2, beta polypeptide and the aliases Ckb1 and Ckb2. Mouse and rat orthologs are both designated Csnk2b.
CSNK2B also features in host-virus biology. On infection with Epstein-Barr virus (EBV), interaction with the viral protein EBNA1 increases the association of CK2 with PML proteins. This raises PML phosphorylation by CK2, triggering polyubiquitylation and degradation of PML. UniProt further reports that CK2 appears to suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter, which inhibits BZLF1 transcription.
As the regulatory subunit of CK2, CSNK2B is relevant to studies of kinase signalling that influences metabolism, transcription, translation and replication.
CSNK2B helps form the tetrameric holoenzyme with the catalytic alpha and alpha prime subunits, making it central to work on CK2 complex composition.
Interaction of CK2 with EBNA1 promotes PML phosphorylation and degradation, linking CSNK2B to research on EBV infection and host defences.
CK2 appears to suppress EBV reactivation by inhibiting BZLF1 transcription at the Z promoter, a topic of interest in herpesvirus latency studies.
CSNK2B encodes the beta subunit of casein kinase II. The alpha and alpha prime subunits are catalytic, while the beta subunit has regulatory functions within the tetrameric holoenzyme. CK2 regulates metabolic pathways, signal transduction, transcription, translation and replication.
CSNK2B is also called casein kinase 2, beta polypeptide, casein kinase II subunit beta, Ckb1 and Ckb2. The NCBI Gene summary reports two transcript variants that encode different isoforms of the protein.
Yes. UniProt reports that during Epstein-Barr virus infection, EBNA1 interaction increases CK2 association with PML proteins, leading to PML phosphorylation, polyubiquitylation and degradation. CK2 also appears to suppress EBV reactivation. Mouse and rat orthologs are named Csnk2b; check the datasheet of any product for its validated reactivity.
Other casein kinase 2 subunits and casein kinase 1 family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P67870; product specifications from Assay Genie datasheets.