RGCC
RGCC (regulator of cell cycle, also known as RGC-32, RGC32, bA157L14.2 and C13orf15) is a small cytoplasmic and nuclear protein that modulates the activity of cell cycle-specific kinases. It is induced by p53 after DNA damage and is linked to cell cycle progression and fibrosis. Browse Assay Genie's current range of RGCC research reagents below, or read on for the biology behind the target.
RGCC modulates the activity of cell cycle-specific kinases. It enhances CDK1 activity, and NCBI Gene reports that it can associate with cell division cycle 2 protein and increase its kinase activity. The protein also forms a complex with polo-like kinase 1. It is thought to contribute to the regulation of cell cycle progression, although in different assays and cell types, overexpression of RGCC has been shown to either activate or suppress the cell cycle.
The RGCC protein changes location with the cell cycle. It sits in the cytoplasm during interphase and moves to centrosomes during mitosis. It also translocates to the nucleus when cells are treated with sublytic levels of complement system proteins, which activate the cell cycle. The RGCC gene is induced by p53 in response to DNA damage, which places it downstream of a major genome-surveillance pathway. In glioma cells, RGCC may inhibit growth by promoting arrest of mitotic progression at the G2/M transition.
RGCC is also described as a fibrogenic factor. It contributes to the pathogenesis of renal fibrosis through fibroblast activation. The gene was first known as chromosome 13 open reading frame 15 (C13orf15), and the name RGC-32 reflects its response gene to complement activity. Mouse and rat both carry an Rgcc ortholog, so the protein can be studied in common rodent models alongside human material.
RGCC enhances CDK1 activity and associates with polo-like kinase 1, making it a useful subject for studying kinase regulation across the cell cycle.
The RGCC gene is induced by p53 after DNA damage, linking it to checkpoint signalling and cell cycle responses to genotoxic stress.
RGCC may inhibit glioma cell growth by promoting arrest of mitotic progression at the G2/M transition.
RGCC acts as a fibrogenic factor that contributes to renal fibrosis through fibroblast activation.
RGCC modulates the activity of cell cycle-specific kinases. It enhances CDK1 activity, forms a complex with polo-like kinase 1, and is thought to help regulate cell cycle progression. It also acts as a fibrogenic factor in renal fibrosis through fibroblast activation.
RGCC is also called RGC-32, RGC32, bA157L14.2 and C13orf15. The last of these reflects the previous HGNC name, chromosome 13 open reading frame 15. The current name, regulator of cell cycle, describes its proposed role in cell cycle progression.
Yes. Both mouse and rat have an ortholog named Rgcc, so the protein can be studied in rodent models. Check the datasheet of any product for its validated reactivity before choosing a reagent for a given species.
Kinases, tumour suppressors and cell cycle regulators that act alongside RGCC in mitotic control and the DNA damage response.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H4X1; product specifications from Assay Genie datasheets.