HBP1
HBP1 (HMG-box transcription factor 1, also named HMG box-containing protein 1) is a nuclear transcriptional repressor that binds the promoter region of its target genes. It contributes to the regulation of the cell cycle and of the Wnt pathway. Browse Assay Genie's current range of HBP1 research reagents below, or read on for the biology behind the target.
HBP1 acts as a transcriptional repressor. It binds to the promoter region of target genes and shows a preference for the DNA sequence 5'-TTCATTCATTCA-3'. Through this activity it plays a role in the regulation of the cell cycle and of the Wnt pathway. In the Wnt context, HBP1 disrupts the interaction between DNA and TCF4, which provides a route by which it can limit TCF4-dependent transcription.
HBP1 also works alongside other regulators of the cell cycle. Its binding to the histone H1.0 promoter is enhanced by interaction with RB1, linking the protein to the retinoblastoma pathway. The NCBI Gene summary describes the HBP1 gene product as predicted to enable DNA-binding transcription repressor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is predicted to take part in the negative regulation of transcription by RNA polymerase II, as well as in the negative regulation of lipid transport and of reactive oxygen species biosynthetic processes.
The protein is annotated in UniProt as localised to the nucleus, and the NCBI summary places it in nuclear speckles. The official HGNC name is HMG-box transcription factor 1, reflecting the HMG-box DNA-binding domain from which the name derives. The HBP1 protein is also reported as a biomarker of osteoarthritis. A rat ortholog, Hbp1, is recorded for comparative work. Because HBP1 sits at the junction of cell-cycle control, Wnt signalling and transcriptional repression, it is a useful subject for studies of how promoter-bound repressors shape gene expression.
HBP1 plays a role in cell cycle regulation and cooperates with RB1 at the histone H1.0 promoter, making it relevant to proliferation control.
HBP1 regulates the Wnt pathway and disrupts the interaction between DNA and TCF4, so it is studied as a modulator of Wnt-driven transcription.
HBP1 binds promoter regions, preferring 5'-TTCATTCATTCA-3', and is used to examine sequence-specific repression by RNA polymerase II-dependent mechanisms.
HBP1 is described as a biomarker of osteoarthritis, which supports its investigation in joint disease and related gene-expression studies.
HBP1 is a nuclear transcriptional repressor that binds the promoter region of target genes, preferring the sequence 5'-TTCATTCATTCA-3'. It plays a role in regulating the cell cycle and the Wnt pathway, and it disrupts the interaction between DNA and TCF4.
The HGNC name is HMG-box transcription factor 1, and UniProt lists the protein as HMG box-containing protein 1. No other aliases or previous symbols are recorded in the data used here, so HBP1 is the standard symbol for both the gene and the protein.
The NCBI Gene summary describes HBP1 as a biomarker of osteoarthritis. A rat ortholog, Hbp1, is recorded, supporting comparative studies in rodents. Check the datasheet of any product for its validated reactivity.
Wnt-pathway factors, cell-cycle regulators and histone targets connected to HBP1 function.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O60381; product specifications from Assay Genie datasheets.