IFT25
IFT25 (intraflagellar transport 25, also known as HSPB11, HSPCO34, PP25, FAP232, CFAP232 or C1orf41) is a component of the intraflagellar transport complex B. It is required for sonic hedgehog signalling and is essential for male fertility. Browse Assay Genie's current range of IFT25 research reagents below, or read on for the biology behind the target.
IFT25 is a component of the intraflagellar transport (IFT) complex B and is required for sonic hedgehog (SHH) signalling. It is thought to mediate the transport of SHH pathway components within the cilium: it is needed for the export of the SMO and PTCH1 receptors out of the cilium and for the accumulation of GLI2 at the ciliary tip when the SHH pathway is activated. This points to a role in the dynamic movement of SHH signalling molecules inside the cilium. IFT25 is not required for ciliary assembly, and its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells, such as kidney and testis.
The protein is encoded by the IFT25 gene and belongs to the IFT25 family. HGNC places it in two gene groups, the small heat shock proteins and the IFT-B1 complex. It localises to the cilium. NCBI Gene describes it as part of intraciliary transport particle A and predicts that it enables metal ion binding. Predicted biological roles include kidney development, smoothened signalling and spermatogenesis, and it is predicted to act upstream of or within left/right axis specification, lung development and skeletal system development. The mouse ortholog is Ift25.
The gene has carried several names. It was previously designated chromosome 1 open reading frame 41 (C1orf41) and heat shock protein family B (small) member 11 (HSPB11). Functionally, IFT25 is essential for male fertility, spermiogenesis and sperm flagella formation. It also plays a role in early kidney development and may be involved in regulating ureteric bud initiation.
IFT25 is required for SHH signalling and for the ciliary export of SMO and PTCH1 and the accumulation of GLI2 at the ciliary tip.
As a component of IFT complex B, IFT25 helps define how signalling molecules are moved within the cilium, without being needed for ciliary assembly.
IFT25 is essential for male fertility, spermiogenesis and sperm flagella formation, making it relevant to studies of testis biology.
IFT25 plays a role in early kidney development and may regulate ureteric bud initiation, with transport function most evident in ciliated kidney tissue.
IFT25 is a component of the intraflagellar transport complex B and is required for sonic hedgehog signalling. It may mediate transport of SHH components, including export of SMO and PTCH1 from the cilium and accumulation of GLI2 at the ciliary tip. It is not required for ciliary assembly.
IFT25 is also called HSPB11 (heat shock protein family B member 11), HSPCO34, PP25, FAP232, CFAP232 and C1orf41 (chromosome 1 open reading frame 41). The protein is annotated as intraflagellar transport protein 25 homolog and belongs to the IFT25 family.
A mouse ortholog, Ift25, is recorded for this gene; check the datasheet of any product for its validated reactivity. In terms of physiology, IFT25 is essential for male fertility, spermiogenesis and sperm flagella formation, and contributes to early kidney development.
Other intraflagellar transport components and cilia-associated targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y547; product specifications from Assay Genie datasheets.