CDH7
CDH7 (cadherin 7) is a type II classical cadherin, a calcium-dependent cell-cell adhesion molecule of the cadherin superfamily. It binds to itself in a homophilic manner and is also known by the previous name cadherin 7, type 2. Browse Assay Genie's current range of CDH7 research reagents below, or read on for the biology behind the target.
CDH7 is a calcium-dependent cell adhesion protein. Like other cadherins, it preferentially interacts with itself in a homophilic manner when connecting cells, and this behaviour may contribute to the sorting of heterogeneous cell types. The mature protein sits in the cell membrane, where it mediates cell-cell binding.
The CDH7 gene encodes a type II classical cadherin. The protein is built from five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II cadherins, sometimes described as atypical, are defined by the absence of the histidine-alanine-valine (HAV) cell adhesion recognition sequence found in type I cadherins. Alternative splicing produces multiple transcript variants, and at least one of them encodes a preproprotein that is proteolytically processed to give the mature glycoprotein.
HGNC places cadherin 7 in the type II classical cadherins gene group, and the previous name was cadherin 7, type 2. The gene lies in a cluster of cadherin genes on chromosome 18. Mutations in the CDH7 gene may be associated with bipolar disease in human patients. Mouse and rat orthologs are designated Cdh7, which makes comparative work across rodent models straightforward. Related type II cadherins include CDH6, CDH8 and CDH11.
CDH7 mediates calcium-dependent, homophilic cell-cell binding, making it a useful subject for studying how adhesion molecules hold cells together.
Homophilic interactions of cadherins may contribute to the sorting of heterogeneous cell types, a concept that CDH7 helps to explore.
As a type II cadherin lacking the HAV motif, CDH7 allows comparison with type I cadherins and other members of its gene cluster.
Mutations in the CDH7 gene may be associated with bipolar disease, which makes it a candidate of interest in genetic studies of the disorder.
CDH7 is a calcium-dependent cell-cell adhesion protein in the cell membrane. It interacts preferentially with itself in a homophilic manner, connecting cells and possibly contributing to the sorting of heterogeneous cell types. Check the datasheet of any product for its validated reactivity.
CDH7 is a type II (atypical) classical cadherin, defined by the lack of the HAV recognition sequence found in type I cadherins. Its full name is cadherin 7, and the previous HGNC name was cadherin 7, type 2. Its UniProt name is Cadherin-7.
Mouse and rat both have a Cdh7 ortholog. In humans, mutations in the CDH7 gene may be associated with bipolar disease, according to the NCBI Gene summary. The gene is present in a cluster of cadherin genes on chromosome 18.
Other cadherin family members, including type II classical cadherins and related cell adhesion molecules.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9ULB5; product specifications from Assay Genie datasheets.