SSTR2
SSTR2 (somatostatin receptor 2) is a seven-transmembrane G protein-coupled receptor for somatostatin-14 and somatostatin-28. It couples to inhibition of adenylyl cyclase and acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells. Browse Assay Genie's current range of SSTR2 research reagents below, or read on for the biology behind the target.
SSTR2 is a receptor for somatostatin-14 and somatostatin-28. It is coupled through pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase, and it also stimulates phosphotyrosine phosphatase and phospholipase C through both pertussis toxin insensitive and sensitive G proteins. It inhibits calcium entry by suppressing voltage-dependent calcium channels. In pancreatic alpha- and beta-cells, SSTR2 is the functionally dominant somatostatin receptor and mediates the inhibitory effect of somatostatin-14 on hormone secretion.
Beyond secretion, SSTR2 inhibits cell growth by enhancing MAPK1 and MAPK2 phosphorylation, followed by up-regulation of CDKN1B. It stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. It also mediates negative regulation of insulin receptor signalling through PTPN6, and it inactivates SSTR3 function following heterodimerisation. UniProt lists its subcellular locations as the cell membrane and cytoplasm.
The SSTR2 gene encodes a member of the G protein-coupled receptor 1 family, belonging to the HGNC somatostatin receptor group. Like other family members it has seven transmembrane segments. NCBI Gene notes that somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins, and that its effects are probably mediated by a family of tissue-specifically expressed G protein-coupled receptors. SSTR2 is expressed at highest levels in cerebrum and kidney. Mouse and rat both have an Sstr2 ortholog, which supports comparative work on this receptor.
SSTR2 mediates somatostatin-14 inhibition of hormone secretion in pancreatic alpha- and beta-cells, making it central to studies of islet regulation.
SSTR2 couples to adenylyl cyclase inhibition, phospholipase C stimulation and suppression of voltage-dependent calcium channels through G proteins.
SSTR2 inhibits cell growth by enhancing MAPK1 and MAPK2 phosphorylation and up-regulating CDKN1B.
SSTR2 stimulates neuronal migration and axon outgrowth and may contribute to neuron development and maturation in the developing brain.
SSTR2 is a receptor for somatostatin-14 and -28. Through G proteins it inhibits adenylyl cyclase and calcium entry, and it mediates somatostatin inhibition of hormone secretion in pancreatic alpha- and beta-cells. It also inhibits cell growth and may support neuronal development.
SSTR2 belongs to the somatostatin receptor group within the G protein-coupled receptor 1 family. UniProt reports that it inactivates SSTR3 receptor function following heterodimerisation, so receptor interactions as well as individual subtypes can shape somatostatin responses.
Yes. Mouse and rat each have an ortholog named Sstr2, so the receptor can be studied in common rodent models. Check the datasheet of any product for its validated reactivity before choosing a species.
Other somatostatin receptor subtypes that belong to the same G protein-coupled receptor group as SSTR2.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P30874; product specifications from Assay Genie datasheets.