Eotaxin-3
Eotaxin-3, encoded by the CCL26 gene, is a secreted CC chemokine that attracts eosinophils and basophils. It is also known as MIP-4alpha, IMAC and TSC-1, and it signals through the chemokine receptors CCR3 and CX3CR1. Browse Assay Genie's current range of Eotaxin-3 research reagents below, or read on for the biology behind the target.
Eotaxin-3 (C-C motif chemokine 26) is a chemoattractant for eosinophils and basophils. It acts as a ligand for the C-C chemokine receptor CCR3, and binding to this receptor triggers Ca(2+) mobilisation in eosinophils. Eotaxin-3 also acts as a ligand for the CX3C chemokine receptor CX3CR1, where it induces cell chemotaxis. It is one of three related chemokines that specifically activate CCR3.
The CCL26 gene is one of two CC cytokine genes clustered on the q arm of chromosome 7. Cytokines are secreted proteins involved in immunoregulatory and inflammatory processes, and CC chemokines are characterised by two adjacent cysteines. Eotaxin-3 belongs to the intercrine beta (chemokine CC) family and sits in the HGNC eotaxins gene group. Researchers studying the eotaxin-3 protein typically do so in the context of secreted, extracellular signalling.
Beyond chemotaxis, the protein has antimicrobial activity, with an antibacterial effect reported against S. pneumoniae, S. aureus, non-typeable H. influenzae and P. aeruginosa. Eotaxin-3 may contribute to eosinophil accumulation in atopic diseases. The gene has been catalogued under several names, including small inducible cytokine subfamily A (Cys-Cys), member 26 (SCYA26), and chemokine (C-C motif) ligand 26, alongside the aliases MIP-4alpha, MIP-4a, IMAC and TSC-1.
Eotaxin-3 is a chemoattractant for eosinophils and basophils, making it relevant to work on how these granulocytes are directed to tissues.
The chemokine may contribute to eosinophil accumulation in atopic diseases, which links it to studies of allergic inflammation.
Eotaxin-3 activates CCR3, triggering Ca(2+) mobilisation in eosinophils, and also engages CX3CR1 to induce chemotaxis.
Eotaxin-3 shows antibacterial activity against S. pneumoniae, S. aureus, non-typeable H. influenzae and P. aeruginosa, supporting innate immunity research.
Eotaxin-3 is a secreted chemoattractant for eosinophils and basophils. It binds CCR3, triggering Ca(2+) mobilisation in eosinophils, and also binds CX3CR1 to induce chemotaxis. It additionally shows antibacterial activity against several bacterial species and may contribute to eosinophil accumulation in atopic diseases.
The HGNC symbol is CCL26, for C-C motif chemokine ligand 26. Aliases include MIP-4alpha, MIP-4a, IMAC, TSC-1 and SCYA26. Earlier names were small inducible cytokine subfamily A (Cys-Cys), member 26, and chemokine (C-C motif) ligand 26.
Eotaxin-3 is one of three related chemokines that specifically activate CCR3, and it is also a ligand for CX3CR1. It belongs to the intercrine beta (CC chemokine) family and is grouped with the eotaxins by HGNC.
Other CC chemokines with products at Assay Genie, relevant to chemotaxis and inflammatory signalling research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y258; product specifications from Assay Genie datasheets.