PIM3
PIM3 (Pim-3 proto-oncogene, serine/threonine kinase; formerly pim-3 oncogene) is a cytoplasmic serine/threonine kinase of the PIM subfamily. It can prevent apoptosis, promote cell survival and support protein translation, and it is overexpressed in several tumour types. Browse Assay Genie's current range of PIM3 research reagents below, or read on for the biology behind the target.
PIM3 is a proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. It is proposed to contribute to tumorigenesis by delivering survival signals through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L). It also acts through regulation of cell cycle progression, protein synthesis and MYC transcriptional activity.
Beyond its role in tumour biology, PIM3 can negatively regulate insulin secretion by inhibiting activation of MAPK1/3 (ERK1/2) through SOCS6. It is also involved in the control of energy metabolism, regulating AMPK activity and thereby modulating MYC and PPARGC1A protein levels and cell growth. Researchers studying the PIM3 protein therefore encounter it in both cancer and metabolic signalling contexts.
The PIM3 gene encodes a member of the CAMK Ser/Thr protein kinase group, within the PIM subfamily of the protein kinase superfamily; HGNC also lists it among the PIM kinase family and microRNA protein coding host genes. Its former name was pim-3 oncogene. According to the NCBI Gene summary, PIM3 is overexpressed in haematological and epithelial tumours and is associated with MYC coexpression. It contributes to cell proliferation and survival through signal transduction cascades and provides a selective advantage in tumorigenesis. Mouse and rat both carry a Pim3 ortholog. Related family members include PIM1 and PIM2.
PIM3 is overexpressed in haematological and epithelial tumours and is associated with MYC coexpression, giving a selective advantage in tumorigenesis.
PIM3 phosphorylates BAD, inducing release of Bcl-X(L), which makes it a useful kinase for studying survival signalling and apoptosis prevention.
PIM3 negatively regulates insulin secretion by inhibiting ERK1/2 activation through SOCS6, and modulates AMPK activity, MYC and PPARGC1A levels.
PIM3 regulates cell cycle progression, protein synthesis and MYC transcriptional activity, linking kinase signalling to proliferation.
PIM3 is a serine/threonine kinase that can prevent apoptosis and promote cell survival and protein translation. It phosphorylates BAD, regulates MYC activity and cell cycle progression, and also inhibits insulin secretion via SOCS6 and ERK1/2. It contributes to energy metabolism through AMPK regulation.
The HGNC-approved name is Pim-3 proto-oncogene, serine/threonine kinase, and UniProt calls the protein serine/threonine-protein kinase pim-3. The previous name was pim-3 oncogene. No alternative gene symbols are recorded. It belongs to the PIM subfamily alongside PIM1 and PIM2.
NCBI Gene reports that PIM3 is overexpressed in haematological and epithelial tumours and associated with MYC coexpression. Orthologs named Pim3 exist in mouse and rat. Check the datasheet of any product for its validated reactivity.
Other PIM subfamily kinases that share survival and proliferation signalling roles with PIM3.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q86V86; product specifications from Assay Genie datasheets.