NR1H2
NR1H2 (nuclear receptor subfamily 1 group H member 2), also known as LXR-beta, LXRb, NER, RIP15 and UNR, is a ligand-activated nuclear receptor that regulates transcription. It contributes to lipid homeostasis, cholesterol uptake and inflammatory control. Browse Assay Genie's current range of NR1H2 research reagents below, or read on for the biology behind the target.
NR1H2 is a nuclear receptor with ligand-dependent transcriptional activation activity. It binds preferentially to double-stranded direct repeats carrying the consensus half-site 5'-AGGTCA-3' with a 4-nucleotide spacer (DR-4). Like other liver X receptors, ligand-activated NR1H2 forms obligate heterodimers with retinoid X receptors (RXRs) and regulates genes containing LXR response elements.
The protein regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. It also interplays functionally with RORA in the regulation of genes involved in liver metabolism. In hepatocytes, NR1H2 induces LPCAT3-dependent phospholipid remodelling in endoplasmic reticulum (ER) membranes, which drives SREBF1 processing and lipogenesis. Through LPCAT3, arachidonate is incorporated into ER phosphatidylcholines, increasing membrane dynamics and enabling triacylglycerol transfer to nascent very low-density lipoprotein (VLDL) particles. LPCAT3 also helps counteract lipid-induced ER stress and inflammation, likely by modulating SRC kinase membrane compartmentalisation and limiting the synthesis of lipid inflammatory mediators.
NR1H2 also has an anti-inflammatory role during the hepatic acute phase response, acting as a corepressor by preventing dissociation of the N-Cor corepressor complex. The NR1H2 gene encodes a member of the nuclear hormone receptor family, NR1 subfamily. LXR-alpha (NR1H3) and LXR-beta form the liver X receptor subfamily, which are key regulators of macrophage function. Unlike the inducible LXR-alpha, which is highly expressed in tissues such as liver, intestine and macrophages, LXR-beta is ubiquitously expressed, as reflected in the former name ubiquitously-expressed nuclear receptor.
NR1H2 regulates cholesterol uptake via MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8, making it central to lipid homeostasis studies.
Through LPCAT3, NR1H2 drives phospholipid remodelling, SREBF1 processing and triacylglycerol transfer to nascent VLDL particles in hepatocytes.
NR1H2 acts as a corepressor that limits the hepatic acute phase response and helps counter lipid-induced ER stress and inflammation.
As a ligand-activated receptor that heterodimerises with RXRs at DR-4 elements, NR1H2 is a model for studying nuclear receptor transcriptional control.
NR1H2 is a ligand-activated nuclear receptor that regulates transcription of target genes. It controls cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8, promotes LPCAT3-dependent phospholipid remodelling and lipogenesis in hepatocytes, and acts as a corepressor during the hepatic acute phase response.
NR1H2 is also called LXR-beta (LXRb), NER, NER-I, RIP15 and UNR. UniProt names the protein oxysterols receptor LXR-beta. Earlier names include ubiquitously-expressed nuclear receptor and nuclear receptor subfamily 1, group H, member 2, reflecting its broad expression.
NR1H2 (LXR-beta) and NR1H3 (LXR-alpha) together form the liver X receptor subfamily of nuclear receptors. Both heterodimerise with RXRs. Orthologous genes, named Nr1h2, exist in mouse and rat; check the datasheet of any product for its validated reactivity.
Other liver X receptor family members, NR1 subfamily nuclear receptors and related transcriptional regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P55055; product specifications from Assay Genie datasheets.