KBTBD13
KBTBD13 (kelch repeat and BTB domain containing 13) is a cytoplasmic substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. It is also known as NEM6 and hCG_1645727, and belongs to the BTB domain containing gene group. Browse Assay Genie's current range of KBTBD13 research reagents below, or read on for the biology behind the target.
KBTBD13 acts as a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. In this type of assembly, the adapter is the component that brings specific substrates to the ligase machinery, so it contributes to determining which proteins are targeted for ubiquitination. The exact function of this family member has yet to be determined, and the identity of its substrates is not defined in the sources used here.
The KBTBD13 gene belongs to a family of genes encoding proteins that contain a BTB domain and several kelch repeats. The BTB domain functions as a protein-protein interaction module, including the ability to self-associate or to interact with proteins that lack a BTB domain. The kelch motif typically occurs in groups of five to seven repeats and has been found in proteins with diverse functions. The human protein is localised to the cytoplasm, and a mouse ortholog, Kbtbd13, is recognised.
Known functions across the wider BTB-kelch family include transcription regulation, ion channel tetramerization and gating, protein ubiquitination or degradation, and cytoskeleton regulation. HGNC lists the gene as kelch repeat and BTB domain containing 13, with the previous name kelch repeat and BTB (POZ) domain containing 13. Alternative designations include hCG_1645727 and NEM6. Because the function remains incompletely characterised, KBTBD13 is of interest to researchers studying how CUL3-based ligases recognise their targets.
KBTBD13 is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ligase, making it relevant to studies of substrate selection in ubiquitination.
As a BTB and kelch repeat protein, it allows comparison of protein-protein interaction modules across a family with diverse roles.
The BTB domain mediates self-association and binding to non-BTB proteins, so KBTBD13 is a candidate for interaction and complex studies.
The exact function of this family member is still to be determined, leaving open questions on its substrates and cellular role.
KBTBD13 is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex, and it is found in the cytoplasm. NCBI Gene notes that the exact function of this family member has yet to be determined.
The full name is kelch repeat and BTB domain containing 13, previously kelch repeat and BTB (POZ) domain containing 13. Aliases include NEM6 and hCG_1645727. UniProt names the protein Kelch repeat and BTB domain-containing protein 13.
A mouse ortholog, Kbtbd13, is listed for the human gene. The BTB and kelch repeat architecture is shared across a family of genes, though the function of this member is undetermined. Check the datasheet of any product for its validated reactivity.
Other BTB-kelch family members and components of the CUL3-based E3 ubiquitin ligase complex.
Gene and protein annotations from HGNC, NCBI Gene and UniProt C9JR72; product specifications from Assay Genie datasheets.