GNA13
GNA13 (G protein subunit alpha 13, also known as G13) is a G-alpha subunit of the G(12) subfamily that transduces signals from transmembrane receptors. It activates RhoA through RhoGEFs and so links G protein-coupled receptor signalling to Rho-dependent responses. Browse Assay Genie's current range of GNA13 research reagents below, or read on for the biology behind the target.
Guanine nucleotide-binding proteins (G proteins) act as modulators or transducers in many transmembrane signalling systems. GNA13 is one such alpha subunit. It binds and activates the RhoGEFs ARHGEF1 (p115RhoGEF), ARHGEF11 (PDZ-RhoGEF) and ARHGEF12 (LARG), and these in turn activate the effector RhoA. GNA13-dependent Rho signalling subsequently regulates the transcription factor AP-1 (activating protein-1). NCBI Gene describes the protein as enabling G protein activity and as involved in the Rho-activating G protein-coupled receptor signalling pathway.
The GNA13 protein belongs to the G-alpha family and the G(12) subfamily, and HGNC places the gene in the group of G protein subunits alpha, group 12/13. UniProt lists its subcellular locations as the cell membrane, melanosome, cytoplasm and nucleus, while NCBI Gene reports it in the cytosol and nucleus and as active in the cytoplasm. The mouse and rat orthologs are both named Gna13. The GNA13 gene was formerly named guanine nucleotide binding protein (G protein), alpha 13, and the aliases G13 and MGC46138 are also in use.
Several functions are described for GNA13 beyond Rho activation. It promotes tumour cell invasion and metastasis by activating the RhoA/ROCK signalling pathway, and it inhibits CDH1-mediated cell adhesion through a process independent of Rho activation. In lymphoid follicles it transmits P2RY8- and S1PR2-dependent signals that inhibit germinal centre B cell growth and migration outside the germinal centre niche. These roles make GNA13 a useful subject for studies of G protein signalling, cell migration and adhesion.
GNA13 activates RhoA through ARHGEF1, ARHGEF11 and ARHGEF12, making it a key entry point for studying Rho-dependent signalling downstream of GPCRs.
GNA13 promotes tumour cell invasion and metastasis by activating the RhoA/ROCK pathway, so it is studied in cancer cell migration.
In lymphoid follicles, GNA13 transmits P2RY8- and S1PR2-dependent signals that restrict germinal centre B cell growth and migration.
GNA13 inhibits CDH1-mediated cell adhesion independently of Rho and, through Rho signalling, regulates the transcription factor AP-1.
GNA13 is a G protein alpha subunit that transduces signals from transmembrane receptors. It binds and activates RhoGEFs (ARHGEF1, ARHGEF11 and ARHGEF12), which activate RhoA, and this Rho signalling regulates AP-1. It also inhibits CDH1-mediated cell adhesion independently of Rho.
The HGNC full name is G protein subunit alpha 13, and UniProt calls the protein guanine nucleotide-binding protein subunit alpha-13. Aliases include G13 and MGC46138, and the previous gene name was guanine nucleotide binding protein (G protein), alpha 13.
Yes. Mouse and rat both have an ortholog named Gna13, so the gene can be studied in common rodent models. GNA13 belongs to the G(12) subfamily of the G-alpha family. Check the datasheet of any product for its validated reactivity.
Other G protein alpha subunits, including the G(12) subfamily partner GNA12, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14344; product specifications from Assay Genie datasheets.