BASP1
BASP1 (brain abundant membrane attached signal protein 1) is a membrane-bound protein also known as NAP-22, NAP22, CAP23 and CAP-23. It carries PEST motifs and several transient phosphorylation sites, and is N-terminally myristoylated. Browse Assay Genie's current range of BASP1 research reagents below, or read on for the biology behind the target.
BASP1 is a membrane-bound protein that belongs to the BASP1 family. According to the NCBI Gene summary, it contains several transient phosphorylation sites and PEST motifs, and it undergoes N-terminal myristoylation, a lipid modification consistent with its association with the cell membrane. UniProt records its subcellular location as the cell membrane and the growth cone, a type of cell projection.
PEST sequences typically occur in proteins with high turnover rates, and their conservation among different species supports their functional significance. The presence of these motifs in BASP1 therefore points to a protein whose levels are tightly regulated. The NCBI summary also notes that the immunological characteristics of the protein are species specific, which is worth bearing in mind when choosing reagents for work across species.
The human BASP1 gene encodes this protein, and alternative splicing produces multiple transcript variants that all encode the same protein. The mouse and rat orthologs are both named Basp1. The protein has been described under several names, including brain acid soluble protein 1, NAP-22 and CAP-23, so literature searches benefit from using all of these aliases alongside the symbol and the previous name, brain abundant, membrane attached signal protein 1.
BASP1 is localised to the growth cone, making it a relevant protein for studying this cell projection structure.
N-terminal myristoylation and transient phosphorylation sites make BASP1 a useful model for lipid modification and membrane association.
PEST motifs are typical of proteins with high turnover rates, so BASP1 is of interest in studies of protein stability.
Conserved PEST sequences and species-specific immunological features make BASP1 relevant to comparative work with Basp1 orthologs.
The available annotation describes BASP1 as a membrane-bound protein with transient phosphorylation sites, PEST motifs and N-terminal myristoylation. UniProt places it at the cell membrane and in the growth cone. A detailed functional annotation is not provided in the sources used here.
BASP1 is also called NAP-22, NAP22, CAP23 and CAP-23. UniProt names it brain acid soluble protein 1, and a previous HGNC name was brain abundant, membrane attached signal protein 1. Alternative splicing gives multiple transcript variants, but they encode the same protein.
Mouse and rat both have a Basp1 ortholog. The NCBI summary notes that conservation of PEST-containing proteins across species supports their functional significance, but that the immunological characteristics of this protein are species specific. Check the datasheet of any product for its validated reactivity.
Other membrane-associated and neuronal growth cone proteins with research products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P80723; product specifications from Assay Genie datasheets.