PDE4A
PDE4A (phosphodiesterase 4A, also known as DPDE2) is a cAMP-specific cyclic nucleotide phosphodiesterase of the PDE4 subfamily. It efficiently hydrolyses the second messenger cAMP, and so helps set the cellular concentration of this signalling molecule. Browse Assay Genie's current range of PDE4A research reagents below, or read on for the biology behind the target.
PDE4A is an enzyme that efficiently hydrolyses cAMP, a second messenger that regulates and mediates many cellular responses to extracellular signals. By controlling the cellular concentration of cAMP, the PDE4A protein plays a key role in many important physiological processes. It belongs to the cyclic nucleotide phosphodiesterase family and the PDE4 subfamily, and is classed by its EC number as a 3',5'-cyclic-AMP phosphodiesterase.
In UniProt, PDE4A is annotated to the perinuclear region of the cytoplasm, the ruffle membrane of cell projections, the cytosol and membranes. The PDE4A gene is listed by HGNC within the phosphodiesterases gene group. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, which is worth bearing in mind when interpreting results from any PDE4A antibody or PDE4A ELISA kit.
The symbol DPDE2 is an alias for the gene. Earlier HGNC names describe it as phosphodiesterase 4A, cAMP-specific, and as the dunce (Drosophila)-homolog phosphodiesterase E2, which reflects its relationship to the Drosophila dunce cAMP phosphodiesterase. Mouse and rat both have an ortholog named Pde4a, so comparative work across these species can use the same gene nomenclature. Other PDE4 subfamily members include PDE4B and PDE4D.
PDE4A hydrolyses cAMP, a second messenger that mediates cellular responses to extracellular signals, making it a point of control in cAMP pathways.
As a member of the PDE4 subfamily with EC 3.1.4.53, PDE4A is a reference cAMP-specific enzyme for comparing cyclic nucleotide phosphodiesterases.
Alternatively spliced transcripts encode different PDE4A isoforms, which makes the gene relevant to studies of isoform-specific roles.
PDE4A is annotated to the perinuclear region, cytosol, membranes and ruffle membrane, supporting work on where cAMP is regulated in the cell.
PDE4A is a cyclic nucleotide phosphodiesterase of the PDE4 subfamily that efficiently hydrolyses cAMP. Because cAMP mediates cellular responses to extracellular signals, regulating its concentration lets PDE4A influence many physiological processes.
PDE4A is also known as DPDE2. Earlier names include phosphodiesterase 4A, cAMP-specific, and the dunce (Drosophila)-homolog phosphodiesterase E2. Alternatively spliced transcript variants encode different isoforms, and UniProt lists the protein as 3',5'-cyclic-AMP phosphodiesterase 4A.
Yes. Mouse and rat each have an ortholog named Pde4a, so the same gene name is used in all three species. Check the datasheet of any product for its validated reactivity.
Other PDE4 subfamily members and cyclic nucleotide phosphodiesterases involved in second messenger signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P27815; product specifications from Assay Genie datasheets.