DPP7
DPP7 (dipeptidyl peptidase 7, also known as DPPII or DPP2) is a post-proline cleaving aminopeptidase of the peptidase S28 family. It contributes to the degradation of some oligopeptides and is expressed in quiescent lymphocytes. Browse Assay Genie's current range of DPP7 research reagents below, or read on for the biology behind the target.
DPP7 is a serine protease that cleaves after proline residues, acting as a post-proline cleaving aminopeptidase. Its annotated role is in the degradation of some oligopeptides. The enzyme is active at both acidic and neutral pH, and it shows strong sequence homology with prolylcarboxypeptidase. UniProt places it in the peptidase S28 family, and HGNC lists it within the DASH family of dipeptidyl peptidase-related proteins.
The DPP7 gene encodes a protein of the same name, catalogued by UniProt as dipeptidyl peptidase 2. It is localised to the lysosome and cytoplasmic vesicles, and it is also found in secreted form. According to the NCBI Gene summary, it is expressed in quiescent lymphocytes. Mouse and rat each carry a Dpp7 ortholog, so the enzyme can be studied in common rodent models.
Resting lymphocytes are maintained through suppression of apoptosis. This quiescent state is disrupted when DPP7 activity is inhibited, which links the enzyme to the survival of resting lymphocytes. The protein has also been called DPPII and DPP2, and the gene was formerly named dipeptidylpeptidase 7. Researchers using a DPP7 antibody, DPP7 ELISA kit or recombinant DPP7 protein should take care to distinguish it from other dipeptidyl peptidases such as DPP4, DPP8 and DPP9, which share part of the name but are distinct gene products.
DPP7 is expressed in resting lymphocytes, and inhibiting it disrupts the apoptosis suppression that maintains their quiescent state.
DPP7 plays an important role in the degradation of some oligopeptides, making it relevant to studies of peptide turnover.
DPP7 localises to the lysosome and cytoplasmic vesicles, which makes it a subject for work on lysosomal peptidase function.
As a post-proline cleaving aminopeptidase active at acidic and neutral pH, DPP7 is useful for comparing S28 family peptidases.
DPP7 is a post-proline cleaving aminopeptidase that plays an important role in the degradation of some oligopeptides. It is a serine protease active at both acidic and neutral pH. It is also needed to maintain apoptosis suppression in resting lymphocytes.
DPP7 is also called DPPII and DPP2, and UniProt names the protein dipeptidyl peptidase 2. HGNC lists the former gene name as dipeptidylpeptidase 7. The enzyme carries the EC number 3.4.14.2. Check the datasheet of any product for its validated reactivity.
DPP7 belongs to the peptidase S28 family and is listed in the HGNC DASH family. It has strong sequence homology with prolylcarboxypeptidase. Mouse and rat both have a Dpp7 ortholog, so it can be studied in rodent systems.
Other dipeptidyl peptidases and DASH family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UHL4; product specifications from Assay Genie datasheets.