HSPB7
HSPB7 (heat shock protein family B (small) member 7, also known as cvHSP) is a member of the small heat shock protein family that can heterodimerise with related heat shock proteins. Defects in the HSPB7 gene are associated with advanced heart failure. Browse Assay Genie's current range of HSPB7 research reagents below, or read on for the biology behind the target.
HSPB7 belongs to the small heat shock protein (HSP20) family. According to the NCBI Gene summary, the encoded protein can heterodimerise with similar heat shock proteins, a property typical of how small heat shock proteins assemble and interact with one another. The HSPB7 protein has been reported in the cytoplasm and the nucleus, including the nuclear Cajal body.
The human HSPB7 gene is classified by HGNC within the small heat shock proteins gene group. UniProt lists the protein as heat shock protein beta-7, and the gene carries the alias cvHSP. Mouse and rat both have an orthologous Hspb7 gene, which allows the protein to be studied in common model organisms.
HSPB7 is of interest in cardiovascular and cancer research. Defects in the gene are associated with advanced heart failure. In addition, the encoded protein may act as a tumour suppressor in the p53 pathway, and defects in the gene have been associated with renal cell carcinoma. Earlier nomenclature described the gene as heat shock 27 kDa protein family, member 7 (cardiovascular), which explains the cvHSP alias. Researchers studying HSPB7 antibody or HSPB7 ELISA kit approaches typically do so in the context of these cardiac and tumour-related roles, alongside related small heat shock proteins.
Defects in the HSPB7 gene are associated with advanced heart failure, making it a target of interest in cardiac disease studies.
HSPB7 can heterodimerise with similar heat shock proteins, so it is relevant to studies of small heat shock protein assembly.
HSPB7 may be a tumour suppressor in the p53 pathway, supporting its study in cancer signalling.
Defects in the HSPB7 gene have been associated with renal cell carcinoma, a link explored in kidney cancer research.
HSPB7 is a small heat shock protein that can heterodimerise with similar heat shock proteins. It may act as a tumour suppressor in the p53 pathway, and defects in its gene are associated with advanced heart failure. Its precise molecular function is not detailed in the UniProt annotation.
HSPB7 is the HGNC symbol for heat shock protein family B (small) member 7. UniProt names the protein heat shock protein beta-7, and cvHSP is a previous symbol. Older names read heat shock 27 kDa protein family, member 7 (cardiovascular).
Mouse and rat both have an Hspb7 ortholog, so the gene is conserved across common model species. In humans, HSPB7 defects are associated with advanced heart failure and renal cell carcinoma. Check the datasheet of any product for its validated reactivity.
Other small heat shock proteins and related heat shock protein targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UBY9; product specifications from Assay Genie datasheets.