CUL5
CUL5 (cullin 5, also known as VACM-1) is a member of the cullin family and acts as a scaffold in Cul5-RING ubiquitin ligase complexes. It is linked to proteasome-mediated, ubiquitin-dependent protein degradation and is active in the nucleus. Browse Assay Genie's current range of CUL5 research reagents below, or read on for the biology behind the target.
CUL5 is a scaffold protein that enables the assembly of Cul5-RING ubiquitin ligase complexes. According to the NCBI Gene summary, it has ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. It is involved in proteasome-mediated, ubiquitin-dependent protein catabolic processes and in protein K11-linked ubiquitination, and it takes part in the negative regulation of cell-substrate junction organisation.
The CUL5 gene encodes cullin-5, a member of the cullin family, which HGNC classifies in the Cullins gene group. The protein is active in the nucleus and is located at sites of DNA damage. Mouse and rat orthologs, both named Cul5, are recorded, so the gene can be studied across common model organisms.
CUL5 is also known as VACM-1. In the context of microbial infection, UniProt notes that cullin-5 seems to be involved in the proteasomal degradation of p53/TP53 stimulated by the adenovirus E1B-55 kDa protein. Researchers studying the ubiquitin-proteasome system often examine CUL5 alongside other cullins, such as CUL1, CUL2, CUL3, CUL4A and CUL7, to compare how each scaffold organises its own ligase complex.
CUL5 scaffolds Cul5-RING ligase complexes that support proteasome-mediated, ubiquitin-dependent protein catabolism, making it relevant to protein turnover studies.
The protein is involved in K11-linked ubiquitination, so it is of interest for work on ubiquitin chain types and ligase activity.
CUL5 is located at sites of DNA damage, which makes it a candidate for studies of nuclear stress responses.
Cullin-5 appears to contribute to adenovirus E1B-55 kDa-stimulated degradation of p53/TP53, linking it to viral hijacking of host ubiquitin machinery.
CUL5 acts as a scaffold for Cul5-RING ubiquitin ligase complexes. It binds ubiquitin protein ligases and contributes to proteasome-mediated, ubiquitin-dependent protein catabolism and K11-linked ubiquitination. It is active in the nucleus and is found at sites of DNA damage.
The HGNC symbol is CUL5 and the approved name is cullin 5. UniProt lists the protein as Cullin-5, and VACM-1 is a recognised alias. The protein belongs to the cullin family, which HGNC groups as Cullins.
Mouse and rat both have an ortholog named Cul5. UniProt reports that cullin-5 seems to be involved in proteasomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. Check the datasheet of any product for its validated reactivity.
Other cullin family scaffold proteins involved in ubiquitin ligase complexes and protein degradation.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q93034; product specifications from Assay Genie datasheets.