MFAP5
MFAP5 (microfibril associated protein 5, also known as MAGP2 or MP25) is a secreted glycoprotein found in the extracellular matrix, where it is a component of elastin-associated microfibrils. It belongs to the MFAP family and has proposed roles in cell attachment, vessel integrity and haematopoiesis. Browse Assay Genie's current range of MFAP5 research reagents below, or read on for the biology behind the target.
MFAP5 is a structural component of the extracellular matrix. It is a constituent of elastin-associated microfibrils, and it promotes the attachment of cells to these microfibrils through alpha-V-beta-3 integrin. This links the microfibrillar scaffold to cell-surface adhesion, which makes the MFAP5 protein relevant to studies of matrix organisation and cell-matrix interaction.
UniProt annotates MFAP5 as a possible regulator in the cardiovascular system. It could regulate growth factors or take part in cell signalling to maintain the integrity of large vessels. It may also play a role in haematopoiesis. In mice, deficiency of the gene results in neutropenia, which supports a connection between this matrix protein and the haematopoietic system.
The MFAP5 gene encodes a microfibril-associated glycoprotein of about 25 kD according to NCBI Gene, which explains the alias MP25. The other alias, MAGP2, reflects its relationship to microfibril-associated glycoproteins. The gene was previously named microfibrillar associated protein 5, and it belongs to the MFAP family. Alternate splicing gives multiple transcript variants that encode different isoforms. The mouse ortholog is Mfap5, and mouse models have been central to understanding its function. Researchers working on an MFAP5 antibody or MFAP5 ELISA kit are usually studying extracellular matrix biology, vascular integrity or the matrix environment of blood cell development.
MFAP5 is a component of elastin-associated microfibrils of the extracellular matrix, so it is relevant to studies of microfibril composition and organisation.
MFAP5 promotes cell attachment to microfibrils through alpha-V-beta-3 integrin, making it a useful target for integrin-mediated adhesion research.
In the cardiovascular system, MFAP5 could regulate growth factors or participate in cell signalling that maintains large vessel integrity.
MFAP5 may play a role in haematopoiesis, and its deficiency in mice results in neutropenia.
MFAP5 is a component of elastin-associated microfibrils in the extracellular matrix. It promotes cell attachment to microfibrils via alpha-V-beta-3 integrin. It may also regulate growth factors or cell signalling to maintain large vessel integrity, and may play a role in haematopoiesis.
MFAP5 is also known as MAGP2 and MP25, and its previous name was microfibrillar associated protein 5. NCBI Gene reports that alternate splicing produces multiple transcript variants encoding different isoforms. UniProt lists Q13361 as the reference entry.
The mouse has an ortholog, Mfap5. Mice lacking the gene develop neutropenia, which points to a role in the haematopoietic system. Check the datasheet of any product for its validated reactivity before using it in a given species.
Other MFAP family members and microfibril-associated proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13361; product specifications from Assay Genie datasheets.