PLXDC2
PLXDC2 (plexin domain containing 2, also known as TEM7R) is a membrane protein of the plexin family. UniProt annotates it as a protein that may play a role in tumour angiogenesis. Browse Assay Genie's current range of PLXDC2 research reagents below, or read on for the biology behind the target.
PLXDC2, or plexin domain-containing protein 2, is a membrane protein that belongs to the plexin family. The functional annotation for the protein is limited: UniProt records that it may play a role in tumour angiogenesis, the process by which tumours develop new blood vessels. The detailed molecular mechanism is not described in the sources used for this page, so the PLXDC2 protein is best regarded as a candidate regulator in this setting rather than a fully characterised one.
The human PLXDC2 gene is named for its plexin domain and is also known by the aliases TEM7R, FLJ14623 and PLXDC2-OT. The mouse ortholog is Plxdc2. Information from the Alliance of Genome Resources places the gene product in the nuclear body, which sits alongside its UniProt classification as a membrane protein and may be relevant when choosing the compartment or fraction to study.
The related family member PLXDC1 carries the same plexin domain-containing designation, and the two are often considered together when researchers compare plexin domain-containing proteins. Researchers studying PLXDC2 typically focus on its link to angiogenesis, its subcellular localisation and how it relates to other plexin family proteins. Reagents for detecting the PLXDC2 gene product, such as a PLXDC2 antibody or PLXDC2 ELISA kit, support this kind of work.
UniProt annotates PLXDC2 as a protein that may play a role in tumour angiogenesis, making it a candidate of interest in this field.
PLXDC2 belongs to the plexin family, so it is studied alongside related plexin domain-containing proteins such as PLXDC1.
UniProt lists PLXDC2 as a membrane protein, which makes it relevant to studies of cell-surface and membrane-associated proteins.
Genome resource annotation places PLXDC2 in the nuclear body, prompting questions about how its localisation relates to its function.
UniProt states that PLXDC2 may play a role in tumour angiogenesis. It is a membrane protein of the plexin family. Beyond this annotation, the sources used here do not describe a detailed mechanism, so its precise function remains to be fully defined.
PLXDC2 stands for plexin domain containing 2, and UniProt names the protein plexin domain-containing protein 2. Aliases and previous symbols include TEM7R, FLJ14623 and PLXDC2-OT. Check that a given product's target name matches the alias used in your literature.
A mouse ortholog, Plxdc2, is recorded for the human gene. Orthologs in other species, including rat, are not specified in the data used for this page. Check the datasheet of any product for its validated reactivity.
The closest related target is PLXDC1, another plexin domain-containing protein with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6UX71; product specifications from Assay Genie datasheets.