REPIN1
REPIN1 (replication initiator 1) is a sequence-specific, double-stranded DNA-binding protein of the C2H2-type zinc finger group. It is also known as RIP60, AP4, Zfp464 and ZNF464, and is linked to the regulation of genes involved in lipid and glucose handling. Browse Assay Genie's current range of REPIN1 research reagents below, or read on for the biology behind the target.
REPIN1 is a sequence-specific double-stranded DNA-binding protein. It binds ATT-rich and T-rich DNA sequences and facilitates DNA bending. Through this activity it is thought to act as a regulator of transcription, and NCBI Gene predicts a role in the regulation of transcription by RNA polymerase II.
UniProt describes several candidate target genes. REPIN1 may regulate the expression of genes involved in cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation. It may also regulate LCN2 expression, and so influence iron metabolism and apoptosis-related pathways. A further proposed role is the regulation of genes involved in glucose transport, consistent with the predicted involvement of the REPIN1 gene in positive regulation of D-glucose import across the plasma membrane. These roles are described as possible rather than established.
The REPIN1 protein is found in the nucleus, where NCBI Gene places it in the nucleoplasm, and in the cytosol. HGNC classifies it in the C2H2-type zinc finger group. The approved name, replication initiator 1, replaced the earlier name zinc finger protein 464 (RIP60), and the aliases RIP60, AP4, Zfp464 and ZNF464 still appear in the literature. Orthologues are named Repin1 in both mouse and rat, which supports the use of rodent models in REPIN1 research.
REPIN1 binds ATT-rich and T-rich DNA and promotes DNA bending, making it a subject for studies of sequence-specific gene regulation.
REPIN1 may regulate genes for cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation.
REPIN1 may regulate genes involved in glucose transport and is predicted to act in positive regulation of D-glucose import.
REPIN1 may regulate LCN2 expression, which could influence iron metabolism and apoptosis-related pathways.
REPIN1 is a sequence-specific double-stranded DNA-binding protein that binds ATT-rich and T-rich sequences and facilitates DNA bending. It may regulate genes involved in fatty acid import, lipid droplet formation, glucose transport and LCN2 expression. Check the datasheet of any product for its validated reactivity.
REPIN1 stands for replication initiator 1. Its aliases and previous symbols include RIP60, AP4, H_DJ0584D14.12, Zfp464 and ZNF464. The earlier approved name was zinc finger protein 464 (RIP60). UniProt lists the protein as DNA-binding protein REPIN1.
Yes. Mouse and rat both have an orthologue named Repin1. HGNC places the human gene in the C2H2-type zinc finger group. Check the datasheet of any product for its validated reactivity before using it with rodent samples.
Other zinc finger proteins, transcription regulators and lipid and glucose metabolism targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BWE0; product specifications from Assay Genie datasheets.