STAT5
STAT5 (signal transducer and activator of transcription 5A, encoded by STAT5A) is a member of the STAT family of transcription factors. It relays signals from cytokines and growth factors at the cell surface to gene expression in the nucleus, and has also been known as MGF. Browse Assay Genie's current range of STAT5 research reagents below, or read on for the biology behind the target.
STAT5 carries out a dual function: signal transduction and activation of transcription. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases. They then form homo- or heterodimers that translocate to the nucleus, where they act as transcription activators. STAT5 binds to the GAS element and activates prolactin-induced transcription, and it regulates the expression of milk proteins during lactation.
STAT5 mediates the responses of many cell ligands, including IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin and various growth hormones. It also mediates cellular responses to the cytokine KITLG/SCF and other growth factors, and to ERBB4. It may mediate responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. The protein is found in both the cytoplasm and the nucleus, consistent with its role in carrying signals between the two compartments. In the mouse, the counterpart of this gene induces expression of BCL2L1/BCL-X(L), which suggests an antiapoptotic function.
The STAT5A gene belongs to the HGNC groups of SH2 domain containing proteins and the signal transducer and activator of transcription family. Alternatively spliced transcript variants have been found. Orthologues exist in mouse and rat, both named Stat5a. In myeloma and lymphoma associated with a TEL/JAK2 gene fusion, STAT5 activation is independent of cell stimulus and has been shown to be essential for tumorigenesis, which makes it a frequent subject of cancer signalling studies.
STAT5 mediates responses to IL-2, IL-3, IL-7, GM-CSF, erythropoietin and thrombopoietin, making it a central readout of cytokine receptor activation.
In myeloma and lymphoma with a TEL/JAK2 fusion, STAT5 activation is stimulus-independent and essential for tumorigenesis.
STAT5 binds the GAS element, activates prolactin-induced transcription and regulates milk protein expression during lactation.
STAT5 mediates responses to KITLG/SCF, ERBB4 and possibly FGFRs, and in mouse induces BCL-X(L), suggesting an antiapoptotic role.
STAT5 both transduces signals and activates transcription. After phosphorylation by receptor-associated kinases it dimerises and moves to the nucleus. There it binds the GAS element to drive gene expression in response to cytokines and growth factors, including prolactin-induced transcription and milk protein expression during lactation.
The official gene symbol is STAT5A, and the protein is also known as MGF and STAT5. HGNC places it in the STAT family and the SH2 domain containing group. Alternatively spliced transcript variants have been reported for the STAT5 gene.
Mouse and rat both carry a Stat5a orthologue. In the mouse, the counterpart induces BCL-X(L), suggesting an antiapoptotic role. In myeloma and lymphoma with a TEL/JAK2 fusion, STAT5 activation is stimulus-independent and essential for tumorigenesis. Check the datasheet of any product for its validated reactivity.
Other members of the STAT transcription factor family with research products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P42229; product specifications from Assay Genie datasheets.