ZNF329 is annotated in UniProt as a protein that may be involved in transcriptional regulation. Its function has not been characterised in detail, and most of what is known comes from prediction. NCBI Gene, drawing on the Alliance of Genome Resources, lists predicted DNA-binding transcription activator activity specific to RNA polymerase II, together with sequence-specific DNA binding at RNA polymerase II cis-regulatory regions. It is also predicted to take part in the regulation of transcription by RNA polymerase II.

The protein is located in the nucleus, which fits a role in gene regulation. It belongs to the krueppel C2H2-type zinc-finger protein family, and HGNC places the gene in the zinc fingers C2H2-type group. Proteins of this type typically use their zinc finger motifs to engage DNA, so the ZNF329 gene is a candidate for studies of sequence-specific transcriptional control. The mouse ortholog is Znf329.

ZNF329 is the approved HGNC symbol for zinc finger protein 329, and FLJ12586 is a recorded alias. The gene is mapped to 19q13.43. Because direct functional evidence is limited, work on the ZNF329 protein generally begins with expression, localisation and DNA-binding questions, rather than established pathway roles.