TRPC5
TRPC5 (transient receptor potential cation channel subfamily C member 5, also known as PPP1R159) is a multi-pass membrane protein that forms a receptor-activated, non-selective, calcium-permeant cation channel. It belongs to the TRPC branch of the transient receptor potential family. Browse Assay Genie's current range of TRPC5 research reagents below, or read on for the biology behind the target.
TRPC5 forms a receptor-activated, non-selective cation channel that is permeable to calcium. In neurons it mediates calcium-dependent phosphatidylserine externalisation and apoptosis through its association with PLSCR1. It also acts on distinct neuronal populations in the hypothalamus to regulate innate behaviours, including feeding, anxiety (flight, fight and fear), socialisation and maternal care.
The TRPC5 gene encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein found at the cell membrane. It is thought to be active alone or as a heteromultimeric assembly with TRPC1, TRPC3 and TRPC4. It is also reported to interact with several other proteins, including calmodulin, CABP1, enkurin, the Na(+)-H+ exchange regulatory factor NHERF, the interferon-induced GTP-binding protein MX1, the ring finger protein RNF24 and the SEC14 domain and spectrin repeat-containing protein SESTD1.
TRPC5 belongs to the transient receptor family, STrpC subfamily, TRPC5 sub-subfamily. HGNC places it in the ankyrin repeat domain containing group, the protein phosphatase 1 regulatory subunits group and the transient receptor potential cation channel subfamily C group, which accounts for the alias PPP1R159. The mouse ortholog is Trpc5, which supports comparative work on this channel. Researchers studying TRPC5 often look at channel assembly, calcium entry and neuronal circuit function.
TRPC5 forms a receptor-activated, non-selective calcium-permeant cation channel, making it a focus for studies of receptor-coupled calcium entry.
TRPC5 acts on distinct hypothalamic neuronal populations to regulate feeding, anxiety, socialisation and maternal care.
TRPC5 mediates calcium-dependent phosphatidylserine externalisation and apoptosis in neurons through its association with PLSCR1.
TRPC5 acts alone or in heteromultimers with TRPC1, TRPC3 and TRPC4, and interacts with proteins such as calmodulin and NHERF.
TRPC5 forms a receptor-activated, non-selective, calcium-permeant cation channel at the cell membrane. In neurons it mediates calcium-dependent phosphatidylserine externalisation and apoptosis via PLSCR1, and in the hypothalamus it helps regulate feeding, anxiety, socialisation and maternal care.
The HGNC name is transient receptor potential cation channel subfamily C member 5, with the previous name written as transient receptor potential cation channel, subfamily C, member 5. UniProt lists it as short transient receptor potential channel 5, and PPP1R159 is a recorded alias.
A mouse ortholog, Trpc5, is recorded for the human gene, so TRPC5 can be studied in mouse models. Human TRPC5 sits in the TRPC subfamily with six other mammalian TRPC proteins. Check the datasheet of any product for its validated reactivity.
Other TRPC family members and TRPC-associated proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UL62; product specifications from Assay Genie datasheets.