CABLES2 is a protein whose function is annotated in UniProt as unknown, although it is probably involved in the G1-S cell cycle transition. This is the point at which a cell commits to DNA replication, so CABLES2 is of interest to researchers studying how cell division is controlled. UniProt places it in the cyclin family, and its name refers to Cdk5 and Abl enzyme substrate 2, with the UniProt protein name given as CDK5 and ABL1 enzyme substrate 2.

The NCBI Gene summary for the CABLES2 gene is based on predictions. It suggests a role in cell division and in the regulation of the cell cycle. CABLES2 is also predicted to act upstream of or within several processes: the DNA damage response, signal transduction by p53 class mediator, gastrulation and in utero embryonic development. The protein is predicted to be located in the cytosol. These assignments come from computational annotation, so they should be tested experimentally and not assumed.

The human gene was previously designated chromosome 20 open reading frame 150 (C20orf150), and it is also listed under the aliases dJ908M14.2 and ik3-2. The mouse ortholog is Cables2, which makes rodent models a possible route for studying its biology. Because so little is established about CABLES2, work on this CABLES2 protein usually begins with expression, localisation and cell cycle analysis.