CA14
CA14 (carbonic anhydrase 14, previously carbonic anhydrase XIV or CA XIV) is a membrane-associated zinc metalloenzyme of the alpha-carbonic anhydrase family. It catalyses the reversible hydration of carbon dioxide. Browse Assay Genie's current range of CA14 research reagents below, or read on for the biology behind the target.
CA14 catalyses the reversible hydration of carbon dioxide. It belongs to the carbonic anhydrases, a large family of zinc metalloenzymes that take part in a range of biological processes, including respiration, calcification, acid-base balance and bone resorption. Members of the family also contribute to the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. The isoforms differ widely in tissue distribution and in subcellular localisation.
CA14 is assigned to the alpha-carbonic anhydrase family and is predicted to be a type I membrane protein. Within the family it shares its highest sequence similarity with the other transmembrane isoform, CA12. Despite this similarity, the two enzymes show different patterns of tissue-specific expression, so they may play different physiological roles. This makes isoform-specific tools useful when separating the contributions of individual carbonic anhydrases.
The CA14 gene is listed by HGNC within the carbonic anhydrases gene group, and the protein was formerly called carbonic anhydrase XIV. The mouse ortholog is Ca14. Researchers studying the CA14 protein often compare it with other family members, such as the transmembrane CA12 and CA9, to understand how each isoform is specialised.
CA14 is one member of a diverse zinc metalloenzyme family, so it is studied to understand isoform-specific roles in carbon dioxide hydration.
Carbonic anhydrases take part in acid-base balance, making CA14 relevant to work on how membrane-bound isoforms handle carbon dioxide and its hydration products.
CA14 is predicted to be a type I membrane protein, which makes it a subject for research on transmembrane enzyme localisation.
CA14 and CA12 are the two transmembrane isoforms and differ in tissue expression, so comparing them helps define distinct physiological roles.
CA14 catalyses the reversible hydration of carbon dioxide. As a carbonic anhydrase, it belongs to a family of zinc metalloenzymes involved in processes such as respiration, calcification and acid-base balance. It is predicted to be a type I membrane protein.
CA14 is the HGNC symbol for carbonic anhydrase 14. The previous name is carbonic anhydrase XIV, often written CA XIV. UniProt lists the protein as Carbonic anhydrase 14, and no other aliases are recorded in the data used here.
CA14 is an alpha-carbonic anhydrase and shares its highest sequence similarity with CA12, the other transmembrane isoform. The two have different tissue-specific expression patterns and may therefore have different physiological roles. The mouse ortholog is Ca14. Check the datasheet of any product for its validated reactivity.
Other carbonic anhydrase isoforms, including the transmembrane CA12, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9ULX7; product specifications from Assay Genie datasheets.