PKN2
PKN2 (protein kinase N2, also known as PRK2, Pak-2, STK7 and PRKCL2) is a serine/threonine-protein kinase of the protein kinase N family. It is linked to cell cycle regulation, apical junction assembly and the replication of certain viral genomes. Browse Assay Genie's current range of PKN2 research reagents below, or read on for the biology behind the target.
PKN2 is a protein serine/threonine kinase. It belongs to the protein kinase superfamily, within the AGC Ser/Thr protein kinase family and the PKC subfamily, and it is classified under EC 2.7.11.13. Beyond its kinase activity, NCBI Gene annotation describes PKN2 as enabling RNA polymerase binding and histone deacetylase binding, and as part of a protein-containing complex. In the context of microbial infection, UniProt records that PKN2 phosphorylates the hepatitis C virus protein NS5B, which stimulates HCV RNA replication. NCBI Gene likewise lists positive regulation of viral genome replication among its processes.
The PKN2 gene is a member of the protein kinase N family, and HGNC also places it in the C2 domain containing protein kinases group. The HGNC gene groups additionally include small nucleolar RNA protein coding host genes. UniProt lists a broad set of subcellular locations for the PKN2 protein: cytoplasm, nucleus and membrane, together with the lamellipodium, cytoskeleton, cleavage furrow, midbody and cell junctions. This spread of locations fits the cellular processes that NCBI Gene associates with the kinase, including apical junction assembly and positive regulation of the cell cycle.
The approved name, protein kinase N2, replaced the earlier name protein kinase C-like 2. That earlier name is the origin of the previous symbol PRKCL2, and it reflects the kinase's relationship to the PKC subfamily. Other aliases found in the literature include PRK2, Pak-2 and STK7. Orthologues are named Pkn2 in both mouse and rat, which allows the kinase to be studied in common model systems. PKN1 is the closest family member with a page on this site.
NCBI Gene lists positive regulation of the cell cycle among PKN2 processes, and the kinase localises to the cleavage furrow and midbody.
PKN2 is involved in apical junction assembly and is found at cell junctions and in lamellipodia.
PKN2 phosphorylates HCV NS5B and stimulates HCV RNA replication, making it relevant to host-virus interaction research.
As an AGC family kinase with RNA polymerase and histone deacetylase binding activity, PKN2 is studied within protein-containing complexes.
PKN2 is a serine/threonine kinase. NCBI Gene associates it with apical junction assembly, positive regulation of the cell cycle and positive regulation of viral genome replication. UniProt notes that it phosphorylates HCV NS5B, which stimulates HCV RNA replication.
PKN2 is also called PRK2, Pak-2, STK7 and PRKCL2. The HGNC-approved name is protein kinase N2, and the previous name was protein kinase C-like 2. UniProt names the protein serine/threonine-protein kinase N2. Check the datasheet of any product for its validated reactivity.
Yes. The mouse and rat orthologues are both named Pkn2. PKN2 belongs to the AGC Ser/Thr protein kinase family, PKC subfamily, and sits in the protein kinase N family alongside PKN1. Check the datasheet of any product for its validated reactivity.
Other protein kinase N family members and similarly named targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16513; product specifications from Assay Genie datasheets.