BMP-15
BMP-15 (bone morphogenetic protein 15, also known as GDF9B) is a secreted member of the TGF-beta family. It is an oocyte-specific growth and differentiation factor that stimulates folliculogenesis and granulosa cell growth. Browse Assay Genie's current range of BMP-15 research reagents below, or read on for the biology behind the target.
BMP-15 is an oocyte-specific growth and differentiation factor that stimulates folliculogenesis and the growth of granulosa cells. Like other ligands of the TGF-beta superfamily, it binds TGF-beta family receptors, which leads to the recruitment and activation of SMAD transcription factors that regulate gene expression. Through activation of granulosa cells, BMP-15 plays a role in oocyte maturation and follicular development.
The BMP15 gene encodes a secreted preproprotein. This is proteolytically processed to generate subunits that form a disulfide-linked homodimer. Alternatively, the subunits can form a heterodimer with the related protein growth differentiation factor 9 (GDF9). The protein is classed by HGNC in the bone morphogenetic proteins gene group, and UniProt places it in the TGF-beta family. Researchers studying the BMP-15 protein therefore often consider it alongside GDF9 and other BMP ligands.
BMP-15 is also known by the alias GDF9B. Defects in the BMP-15 gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. This makes the factor a common subject in studies of ovarian biology, oocyte-granulosa cell communication and reproductive disorders. A mouse ortholog, Bmp15, is recognised for comparative work.
BMP-15 is an oocyte-derived factor that stimulates folliculogenesis, so it is central to studies of how follicles develop.
The factor stimulates granulosa cell growth and acts through these cells to support oocyte maturation.
Defects in the BMP15 gene cause ovarian dysgenesis and are associated with premature ovarian failure.
As a TGF-beta superfamily ligand, BMP-15 signals via receptors and SMAD transcription factors, and can form heterodimers with GDF9.
BMP-15 is a secreted, oocyte-specific growth and differentiation factor. It stimulates folliculogenesis and granulosa cell growth, and plays a role in oocyte maturation and follicular development by activating granulosa cells through TGF-beta family receptor and SMAD signalling.
BMP-15 is encoded by BMP15 and is also called GDF9B. The preproprotein is proteolytically processed into subunits that form a disulfide-linked homodimer, or a heterodimer with growth differentiation factor 9 (GDF9).
Defects in the BMP15 gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. A mouse ortholog, Bmp15, exists; check the datasheet of any product for its validated reactivity.
Other bone morphogenetic proteins, BMP receptors and regulators of TGF-beta family signalling with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95972; product specifications from Assay Genie datasheets.