COL13A1
COL13A1 encodes the alpha chain of collagen XIII, a nonfibrillar collagen that is anchored in the plasma membrane rather than secreted. The protein, also named collagen alpha-1(XIII) chain, contributes to cell-matrix and cell-cell adhesion during development. Browse Assay Genie's current range of COL13A1 research reagents below, or read on for the biology behind the target.
COL13A1 is involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. The COL13A1 protein may participate in the linkage between muscle fibre and basement membrane, and it binds heparin. At neuromuscular junctions it may play a role in acetylcholine receptor clustering. It may also contribute to endochondral ossification of bone and to branching morphogenesis of the lung.
The COL13A1 gene encodes the alpha chain of one of the nonfibrillar collagens. Unlike most collagens, which are secreted into the extracellular matrix, collagen XIII contains a transmembrane domain and is localised to the plasma membrane, including the postsynaptic cell membrane. Like other collagens, collagen XIII is a trimer, although it is not known whether the trimer contains one or more than one alpha chain isoform. It has been detected at low levels in all connective tissue-producing cells, so it may serve a general function in connective tissues, though its precise function is not established.
Transcripts of the gene undergo complex and extensive splicing involving at least eight exons, and a number of alternatively spliced transcript variants have been described. The full-length nature of some of these variants has not been determined. HGNC classifies the gene among the membrane associated collagens with interrupted triple helices; its previous name was collagen, type XIII, alpha 1. The mouse ortholog is Col13a1.
COL13A1 may play a role in acetylcholine receptor clustering at neuromuscular junctions and is found in the postsynaptic cell membrane.
The protein may participate in linking muscle fibres to the basement membrane, making it relevant to studies of muscle attachment.
COL13A1 may contribute to endochondral ossification of bone and branching morphogenesis of the lung during development.
Collagen XIII is detected at low levels in connective tissue-producing cells and mediates cell-matrix and cell-cell adhesion.
COL13A1 is involved in cell-matrix and cell-cell adhesion interactions needed for normal development. It may link muscle fibres to the basement membrane, binds heparin, and may help cluster acetylcholine receptors at neuromuscular junctions. Its precise function is still not fully established.
Most collagens are secreted into the extracellular matrix. Collagen XIII contains a transmembrane domain and is localised to the plasma membrane. It is a nonfibrillar collagen and a trimer, and its transcripts undergo extensive alternative splicing involving at least eight exons.
A mouse ortholog, Col13a1, is recorded for this gene. The human gene was previously named collagen, type XIII, alpha 1 and belongs to the membrane associated collagens with interrupted triple helices. Check the datasheet of any product for its validated reactivity.
Other collagens, including membrane-associated and nonfibrillar family members, and related extracellular matrix targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q5TAT6; product specifications from Assay Genie datasheets.