TNS4
TNS4 (tensin 4, also known as CTEN) is a focal adhesion-associated tensin family protein that promotes EGF-induced cell migration. It also stabilises the receptors EGFR and MET, and belongs to the SH2 domain containing gene group. Browse Assay Genie's current range of TNS4 research reagents below, or read on for the biology behind the target.
TNS4 links integrin adhesion to growth factor receptor signalling. In response to EGF, it promotes cell migration by displacing the tensin TNS3 from the cytoplasmic tail of integrin ITGB1. This causes TNS3 to dissociate from focal adhesions, actin stress fibres to disassemble and cell migration to begin.
The TNS4 protein also acts on receptor turnover. In the presence of EGF it reduces EGFR ubiquitination, which suppresses ligand-induced degradation of EGFR. It also raises MET protein stability by inhibiting MET endocytosis and the lysosomal degradation that follows, which increases cell survival, proliferation and migration.
The TNS4 gene is listed by HGNC as tensin 4 in the SH2 domain containing group, and CTEN is a recognised alias. UniProt places the protein in the PTEN phosphatase protein family. It localises to focal adhesions and the cytoskeleton within the cytoplasm. NCBI Gene summarises it as predicted to enable actin binding and as involved in intracellular protein localisation, with a presence in the cytosol and at focal adhesions. Mouse and rat both carry a Tns4 ortholog, which makes rodent models a practical route for studying its function.
TNS4 promotes EGF-induced migration by displacing TNS3 from integrin ITGB1, making it a useful focus for studies of focal adhesion disassembly.
By reducing EGFR ubiquitination in the presence of EGF, TNS4 suppresses ligand-induced receptor degradation, which is relevant to receptor trafficking studies.
TNS4 inhibits MET endocytosis and lysosomal degradation, increasing MET stability, cell survival, proliferation and migration.
TNS4 acts at focal adhesions and influences actin stress fibre disassembly, linking integrin adhesion to cytoskeletal remodelling.
TNS4 promotes EGF-induced cell migration by displacing TNS3 from the integrin ITGB1 tail, which leads to focal adhesion dissociation and actin stress fibre disassembly. It also reduces EGFR ubiquitination and stabilises MET by inhibiting its endocytosis and lysosomal degradation.
TNS4 is the HGNC symbol for tensin 4, and UniProt lists the protein as Tensin-4. CTEN is a recognised alias. When searching the literature, use both TNS4 and CTEN so that older papers are included in your results.
Yes. Mouse and rat each have an ortholog named Tns4. UniProt places the human protein in the PTEN phosphatase protein family. For any product, check the datasheet for its validated reactivity before use in rodent work.
Tensin family members, integrin and growth factor receptor partners, and PTEN family proteins relevant to TNS4 biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8IZW8; product specifications from Assay Genie datasheets.