ADAM9
ADAM9 (ADAM metallopeptidase domain 9, also known as MDC9, meltrin gamma, KIAA0021, MCMP and CORD9) is a membrane-anchored member of the ADAM family of disintegrin and metalloproteinase domain proteins. It may act as an alpha-secretase for amyloid precursor protein (APP). Browse Assay Genie's current range of ADAM9 research reagents below, or read on for the biology behind the target.
ADAM9 belongs to the ADAM (a disintegrin and metalloprotease domain) family, whose members are membrane-anchored proteins structurally related to snake venom disintegrins. UniProt annotates the protein as a metalloproteinase that may act as an alpha-secretase for amyloid precursor protein (APP). It is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor, linking it to the release of signalling molecules from the cell surface.
The protein interacts with SH3 domain-containing proteins and binds mitotic arrest deficient 2 beta protein. UniProt lists its subcellular locations as the cell membrane and secreted, consistent with a membrane-anchored protein that can also occur in a released form. Several alternatively spliced transcript variants of the ADAM9 gene have been identified. The mouse ortholog is Adam9.
ADAM family members have been implicated in a variety of processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development and neurogenesis. The protein has also been known as a disintegrin and metalloproteinase domain 9 (meltrin gamma), and the symbol CORD9 reflects its previous designation as cone rod dystrophy 9. Researchers studying ADAM9 commonly use an ADAM9 antibody, ADAM9 ELISA kit or recombinant ADAM9 protein to examine its expression, shedding activity and interactions.
ADAM9 may act as an alpha-secretase for APP, making it relevant to studies of amyloid precursor protein processing.
ADAM9 is involved in TPA-induced shedding of membrane-anchored heparin-binding EGF-like growth factor, a model for growth factor release.
ADAM family proteins are implicated in cell-cell and cell-matrix interactions, which makes ADAM9 a subject for adhesion research.
ADAM9 interacts with SH3 domain-containing proteins and binds mitotic arrest deficient 2 beta protein, supporting interaction and signalling studies.
ADAM9 is a membrane-anchored metalloproteinase that may act as an alpha-secretase for amyloid precursor protein. It is also involved in TPA-induced ectodomain shedding of heparin-binding EGF-like growth factor, and it interacts with SH3 domain-containing proteins and mitotic arrest deficient 2 beta protein.
ADAM9 is also called MDC9, KIAA0021, MCMP, Mltng and CORD9. Earlier names include a disintegrin and metalloproteinase domain 9 (meltrin gamma) and cone rod dystrophy 9. Several alternatively spliced transcript variants of the gene have been identified.
A mouse ortholog, Adam9, exists, so the protein can be studied in mouse models. ADAM9 belongs to the ADAM family, which is related to snake venom disintegrins. Check the datasheet of any product for its validated reactivity.
Other ADAM family metalloproteinases and related ADAMTS proteases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13443; product specifications from Assay Genie datasheets.