PABPC1L
PABPC1L (poly(A) binding protein cytoplasmic 1 like, also known as ePAB, PABPC1L1 and C20orf119) is a cytoplasmic poly(A)-binding protein of the type-1 family. It supports oocyte maturation and early embryo development by regulating the polyadenylation and translation of maternal mRNA. Browse Assay Genie's current range of PABPC1L research reagents below, or read on for the biology behind the target.
PABPC1L is a poly(A)-binding protein involved in oocyte maturation and early embryo development. Members of the polyadenylate-binding protein type-1 family bind the poly(A) tails of mRNAs to regulate mRNA stability and translation. PABPC1L is required for cytosolic mRNA polyadenylation and for the translational activation of maternally stored mRNA in oocytes. This makes it a key factor in the post-transcriptional control that operates when oocytes and early embryos depend on stored transcripts. The protein localises to the cytoplasm, where this regulation takes place.
The human PABPC1L gene is placed in the HGNC gene group of RNA binding motif containing proteins. Its expression is shaped by alternative splicing. The protein-coding splice variant is abundantly expressed in human oocytes. A noncoding splice variant that is subject to nonsense-mediated decay is the predominant variant in somatic tissues. As a result, a functional PABPC1L protein is not expected to accumulate in somatic cells. This is relevant when designing experiments that use PABPC1L antibody or PABPC1L ELISA kit reagents, because the choice of sample context matters for interpreting results.
The mouse ortholog, Pabpc1l, is required for female fertility, which links this family member to reproductive biology. The gene was previously designated chromosome 20 open reading frame 119 (C20orf119), and the protein is also called embryonic poly(A)-binding protein (ePAB). Both names are found in older literature. Researchers studying maternal mRNA regulation, oocyte competence and early development use PABPC1L as a focused marker and mechanistic target.
PABPC1L is involved in oocyte maturation and is required for cytosolic polyadenylation of maternally stored mRNA in oocytes.
The protein contributes to early embryo development through translational activation of maternal mRNA stored in the oocyte.
As a type-1 poly(A)-binding protein, PABPC1L binds mRNA poly(A) tails to regulate transcript stability and translation.
The mouse ortholog is required for female fertility, making PABPC1L relevant to studies of reproductive function.
PABPC1L is a poly(A)-binding protein involved in oocyte maturation and early embryo development. It is required for cytosolic mRNA polyadenylation and translational activation of maternally stored mRNA in oocytes. Like other type-1 family members, it binds mRNA poly(A) tails to regulate stability and translation.
PABPC1L is also known as ePAB (embryonic poly(A)-binding protein), PABPC1L1, dJ1069P2.3 and C20orf119. Earlier names include chromosome 20 open reading frame 119 and poly(A) binding protein, cytoplasmic 1-like. UniProt lists it as polyadenylate-binding protein 1-like.
The protein-coding splice variant is abundantly expressed in human oocytes. In somatic tissues the predominant variant is noncoding and subject to nonsense-mediated decay. Mouse has an ortholog, Pabpc1l, which is required for female fertility. Check the datasheet of any product for its validated reactivity.
Other poly(A)-binding proteins and RNA-binding proteins relevant to mRNA stability, translation and oocyte biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q4VXU2; product specifications from Assay Genie datasheets.