EIF3B
EIF3B (eukaryotic translation initiation factor 3 subunit B, also known as PRT1 and EIF3S9) is a subunit of the eukaryotic translation initiation factor 3 complex. It binds RNA and contributes to translation initiation factor activity in the cytoplasm. Browse Assay Genie's current range of EIF3B research reagents below, or read on for the biology behind the target.
EIF3B is part of the eukaryotic translation initiation factor 3 (eIF3) complex, which acts at the start of protein synthesis. The EIF3B protein enables RNA binding and contributes to translation initiation factor activity. It is involved in translational initiation, including IRES-dependent viral translational initiation, and in viral translational termination-reinitiation. In feline calicivirus (FCV) infection, EIF3B plays a role in the ribosomal termination-reinitiation event that leads to translation of VP2.
The protein belongs to the eIF-3 subunit B family. HGNC places the EIF3B gene in the groups of RNA binding motif containing proteins, eukaryotic translation initiation factor 3 complex subunits, and armadillo like helical domain containing proteins. Within the cell, EIF3B is located in the cytosol and in cytoplasmic stress granules, and it is described as part of the eIF3 complex. Mouse and rat both carry an orthologous gene, Eif3b.
The gene has also been catalogued as PRT1 and EIF3S9, and earlier names include eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa. Researchers studying eIF3 composition, viral hijacking of host translation or stress granule biology often work with EIF3B alongside other eIF3 subunits, using tools such as an EIF3B antibody or EIF3B ELISA kit.
EIF3B contributes to translation initiation factor activity as part of the eIF3 complex, making it relevant to studies of how protein synthesis begins.
EIF3B is involved in IRES-dependent viral translational initiation and in viral translational termination-reinitiation, including VP2 translation in FCV infection.
EIF3B is located in cytoplasmic stress granules, so it is a useful marker for work on translation under cellular stress.
EIF3B enables RNA binding and sits within the RNA binding motif containing gene group, supporting studies of RNA-protein interactions.
EIF3B is a subunit of the eIF3 complex. It enables RNA binding, contributes to translation initiation factor activity and is involved in translational initiation. It also participates in IRES-dependent viral translational initiation and in viral translational termination-reinitiation.
EIF3B is also known as PRT1 and EIF3S9. Previous names include eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa, and eukaryotic translation initiation factor 3, subunit B. UniProt places it in the eIF-3 subunit B family.
Yes. Mouse and rat both have an orthologue named Eif3b, so the gene can be studied in common rodent models. Check the datasheet of any product for its validated reactivity.
Other eIF3 subunits, translation initiation factors and regulators of protein synthesis with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P55884; product specifications from Assay Genie datasheets.