BMP-7
BMP-7 (bone morphogenetic protein 7, also known as OP-1) is a secreted growth factor of the TGF-beta superfamily. It signals through type I and type II receptors to regulate gene expression in embryogenesis, haematopoiesis, neurogenesis and skeletal morphogenesis. Browse Assay Genie's current range of BMP-7 research reagents below, or read on for the biology behind the target.
BMP-7 is a growth factor of the TGF-beta superfamily that plays an important role in embryogenesis, haematopoiesis, neurogenesis and skeletal morphogenesis. It initiates the canonical BMP signalling cascade by associating with the type I receptor ACVR1 and the type II receptor ACVR2A. Once the three components form a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1, which in turn phosphorylates SMAD1/5/8. These SMAD proteins travel to the nucleus and act as activators and repressors of transcription of target genes.
For specific functions, such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, BMP-7 uses BMPR2 as the type II receptor. It can also signal through non-canonical routes, including the P38 MAP kinase cascade, which promotes brown adipocyte differentiation through activation of target genes such as members of the SOX family of transcription factors. BMP-7 also promotes expression of HAMP, an effect that is repressed by its interaction with ERFE.
The BMP7 gene encodes a preproprotein that is proteolytically processed to generate each subunit of a disulfide-linked homodimer. The mature, secreted protein contributes to bone, kidney and brown adipose tissue development. BMP-7 induces ectopic bone formation and may promote fracture healing in human patients. It is a member of the bone morphogenetic proteins gene group and is also known as OP-1.
BMP-7 induces ectopic bone formation and contributes to skeletal morphogenesis, making it a key ligand in studies of bone development and fracture healing.
The BMP-7 homodimer plays a role in kidney development, so it is studied in renal developmental biology.
BMP-7 signals through P38 MAP kinase to promote brown adipocyte differentiation via SOX family target genes.
Acting through ACVR1, ACVR2A, BMPR2 and SMAD1/5/8, BMP-7 is used to study neurogenesis, growth cone collapse and monocyte chemotaxis.
BMP-7 is a secreted TGF-beta superfamily growth factor. It binds ACVR1 and ACVR2A (or BMPR2 for some functions) and activates SMAD1/5/8 to regulate transcription. It contributes to embryogenesis, haematopoiesis, neurogenesis and skeletal morphogenesis, and to bone, kidney and brown adipose tissue development.
Yes. OP-1 is an alias of BMP-7, whose official gene symbol is BMP7 and whose HGNC name is bone morphogenetic protein 7. The gene encodes a preproprotein that is processed into subunits of a disulfide-linked homodimer, the active secreted ligand.
A mouse ortholog, Bmp7, is recorded for this gene. BMP-7 belongs to the TGF-beta family and the bone morphogenetic proteins gene group. Check the datasheet of any product for its validated reactivity.
Other bone morphogenetic proteins, BMP receptors and BMP pathway regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P18075; product specifications from Assay Genie datasheets.