SEPTIN3
SEPTIN3 (septin 3, also known as SEP3 and SEPT3) is a filament-forming cytoskeletal GTPase of the septin family. It is annotated as neuronal-specific septin-3 and may contribute to cytokinesis. Browse Assay Genie's current range of SEPTIN3 research reagents below, or read on for the biology behind the target.
SEPTIN3 is a filament-forming cytoskeletal GTPase. UniProt notes that it may play a role in cytokinesis, although this is marked as a potential function rather than an established one. The protein is listed under the name neuronal-specific septin-3, and it is annotated as localising to the cytoplasm, the cytoskeleton and the synapse.
The SEPTIN3 gene belongs to the septin family of GTPases, whose members are required for cytokinesis. At the protein level, SEPTIN3 belongs to the Septin GTPase family within the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. HGNC places it in the Septins gene group, alongside related genes such as SEPTIN2, SEPTIN4, SEPTIN5, SEPTIN6, SEPTIN7, SEPTIN8 and SEPTIN12. Researchers studying the SEPTIN3 protein will often consider it in the context of these other septins.
According to the NCBI Gene summary, expression of SEPTIN3 is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of the gene has not been determined. Alternative splicing produces several transcript variants that encode different isoforms. The gene is also known by the symbols SEP3 and SEPT3, and orthologues are annotated in both mouse and rat as Septin3. These aliases are worth checking when searching older literature on this target.
SEPTIN3 is a filament-forming cytoskeletal GTPase, making it relevant to studies of how septin filaments are assembled and organised in the cell.
Septin family members are required for cytokinesis, and SEPTIN3 may play a role in this process, so it is of interest in cell division studies.
UniProt describes SEPTIN3 as neuronal-specific septin-3 and places it at the synapse, which makes it a candidate for neuroscience research.
Expression of the SEPTIN3 gene is upregulated by retinoic acid in a human teratocarcinoma cell line, offering a context for differentiation-related work.
SEPTIN3 is a filament-forming cytoskeletal GTPase that may play a role in cytokinesis. NCBI notes that septin family members are required for cytokinesis, but also states that the specific function of this gene has not been determined.
SEPTIN3 is also called SEP3 and SEPT3, and UniProt lists the protein as neuronal-specific septin-3. NCBI reports that alternative splicing yields several transcript variants encoding different isoforms, so check which isoform an experiment addresses.
Orthologues of SEPTIN3 are annotated in mouse and rat, both named Septin3. Species reactivity differs between reagents, so check the datasheet of any product for its validated reactivity.
Other members of the septin GTPase family that are studied alongside SEPTIN3 in cytoskeleton and cytokinesis research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UH03; product specifications from Assay Genie datasheets.