LY86
LY86 (lymphocyte antigen 86), also known as MD-1 and dJ80N2.1, is a secreted protein that may cooperate with CD180 and TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS). It belongs to the MD-2 related lipid recognition domain containing gene group. Browse Assay Genie's current range of LY86 research reagents below, or read on for the biology behind the target.
LY86 is a secreted protein associated with the innate immune response to bacterial lipopolysaccharide. According to UniProt, it may cooperate with CD180 and TLR4 to mediate this response and the resulting cytokine production. It is also important for efficient cell surface expression of CD180, which places LY86 in the same functional context as the CD180 receptor.
The LY86 gene encodes a protein found in the extracellular space. NCBI Gene summarises it as acting upstream of or within positive regulation of the lipopolysaccharide-mediated signalling pathway, and as predicted to be located in the extracellular region. HGNC classifies it in the MD-2 related lipid recognition domain containing group, a grouping that fits its role in recognising bacterial lipid-derived ligands. The mouse ortholog is Ly86.
The protein is known by the alias MD-1 as well as the clone-derived designation dJ80N2.1, and the approved name is lymphocyte antigen 86. Researchers studying LY86 often examine it alongside CD180, TLR4 and LY96 (MD-2) when investigating LPS sensing, innate immune signalling and cytokine production. Whether you are working with the LY86 protein, measuring it with an LY86 ELISA kit or probing it with an LY86 antibody, the key biology is its support of the CD180 and TLR4 axis.
LY86 may cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide.
NCBI Gene describes LY86 as acting upstream of or within positive regulation of lipopolysaccharide-mediated signalling.
UniProt links LY86 to cytokine production downstream of LPS recognition, making it relevant to inflammatory response studies.
LY86 is important for efficient CD180 cell surface expression, so it is relevant to studies of this receptor complex.
LY86 may cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide and cytokine production. It is also important for efficient cell surface expression of CD180. It is a secreted protein found in the extracellular space.
LY86 is the HGNC symbol for lymphocyte antigen 86. The protein is also called MD-1, and dJ80N2.1 is listed as another alias. HGNC places it in the MD-2 related lipid recognition domain containing gene group.
A mouse ortholog, Ly86, is recorded for this gene, which allows comparative work in mouse models of innate immunity. No rat ortholog is listed in the data supplied. Check the datasheet of any product for its validated reactivity.
Other lymphocyte antigens, LPS-recognition proteins and immune pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95711; product specifications from Assay Genie datasheets.