FCER2
FCER2 (Fc epsilon receptor II), also known as CD23, is a B-cell specific low-affinity receptor for immunoglobulin E (IgE) and for CR2/CD21. It regulates IgE production and B cell differentiation, and is also known as CLEC4J, FCErII, FcepsilonRII, CD23A and FCE2. Browse Assay Genie's current range of FCER2 research reagents below, or read on for the biology behind the target.
FCER2 is a low-affinity receptor for immunoglobulin E (IgE) and for CR2/CD21. It has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, it initiates IgE-dependent antigen uptake and presentation to T cells. On macrophages, IgE binding followed by antigen cross-linking induces intracellular killing of parasites through activation of the L-arginine-nitric oxide pathway.
The FCER2 gene encodes a B-cell specific antigen that is found at the cell membrane and also exists as a soluble, secreted form. In its secreted form the protein functions as a potent mitogenic growth factor. NCBI Gene notes that alternatively spliced transcript variants encoding different isoforms have been described, which is relevant when choosing an FCER2 antibody or an FCER2 ELISA kit for a particular form of the protein.
HGNC places FCER2 in the groups CD molecules, C-type lectin domain containing, and Fc receptors, which explains the aliases CD23 and CLEC4J. Earlier names described it as the Fc fragment of IgE receptor II, low affinity, including the CD23A and CD23 designations. The mouse ortholog is Fcer2. Researchers studying the FCER2 gene or FCER2 protein usually do so in the context of IgE biology and B cell function.
FCER2 has an essential role in regulating IgE production, making it a central target for studies of IgE-mediated responses.
The receptor is B-cell specific and contributes to B cell growth and differentiation.
On B cells, FCER2 initiates IgE-dependent antigen uptake and presentation to T cells.
On macrophages, IgE binding and antigen cross-linking via FCER2 trigger parasite killing through the L-arginine-nitric oxide pathway.
FCER2 is a low-affinity receptor for IgE and CR2/CD21. It regulates IgE production and B cell differentiation, drives IgE-dependent antigen uptake and presentation to T cells on B cells, and promotes parasite killing in macrophages via the L-arginine-nitric oxide pathway.
Yes. CD23 is a widely used alias of FCER2. Other names include CLEC4J, FCErII, FcepsilonRII, CD23A and FCE2. Older names refer to the Fc fragment of IgE receptor II, low affinity. The protein exists as membrane-bound and secreted forms, and alternative splicing yields different isoforms.
Yes, the mouse ortholog is Fcer2. No rat ortholog is given in the data supplied for this page. For any product, check the datasheet for its validated reactivity before planning cross-species work.
Other Fc receptors, IgE-pathway proteins and B cell markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P06734; product specifications from Assay Genie datasheets.