AP1M2
AP1M2 (adaptor related protein complex 1 subunit mu 2, also known as HSMU1B, mu2 and AP1-mu2) is the mu 2 subunit of the clathrin-associated adaptor protein complex 1 (AP-1). It contributes to protein sorting in the trans-Golgi network and endosomes. Browse Assay Genie's current range of AP1M2 research reagents below, or read on for the biology behind the target.
AP1M2 is a subunit of the clathrin-associated adaptor protein complex 1, which plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. Adaptor protein complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In this way they link cargo selection to the formation of clathrin-coated vesicles. The AP1M2 protein is capable of interacting with tyrosine-based sorting signals, which is the basis of its role in cargo recognition.
The AP1M2 gene encodes a subunit of the heterotetrameric adaptor-related protein complex 1 (AP-1), and the protein belongs to the adaptor complexes medium subunit family. Within the complex, the mu subunit is the medium subunit. UniProt records the protein at the Golgi apparatus and at the membrane of clathrin-coated cytoplasmic vesicles, consistent with its function in membrane trafficking. NCBI Gene reports that alternative splicing of the gene results in multiple transcript variants. Mouse and rat both carry an orthologous gene, Ap1m2.
HGNC places the gene in the adaptor related protein complex 1 group. The approved name is adaptor related protein complex 1 subunit mu 2, and earlier names include adaptor-related protein complex 1, mu 2 subunit. The symbol HSMU1B and the names mu2 and AP1-mu2 also appear in the literature. AP1M2 is often studied alongside AP1M1, the other AP-1 mu subunit, and alongside the AP-2 and AP-3 adaptor complexes, which act at other membrane compartments.
AP1M2 acts in protein sorting at the trans-Golgi network and endosomes, making it relevant to studies of vesicular transport.
As part of AP-1, AP1M2 helps recruit clathrin to membranes, so it features in work on coated vesicle assembly.
AP1M2 interacts with tyrosine-based sorting signals, supporting research into how adaptor complexes recognise transmembrane cargo tails.
Comparing AP1M2 with related medium subunits helps clarify how the AP-1, AP-2 and AP-3 complexes differ in function.
AP1M2 is a subunit of the clathrin-associated adaptor protein complex 1. The complex acts in protein sorting in the trans-Golgi network and endosomes, recruiting clathrin to membranes and recognising sorting signals in the cytosolic tails of transmembrane cargo. AP1M2 can bind tyrosine-based sorting signals.
The approved HGNC name is adaptor related protein complex 1 subunit mu 2. UniProt lists it as AP-1 complex subunit mu-2, and aliases include HSMU1B, mu2 and AP1-mu2. Older names read adaptor-related protein complex 1, mu 2 subunit. NCBI Gene notes that alternative splicing gives multiple transcript variants.
Yes. Mouse and rat each have an orthologous gene named Ap1m2. The protein belongs to the adaptor complexes medium subunit family, which is shared across the AP complexes. Check the datasheet of any product for its validated reactivity.
Other adaptor protein complex subunits involved in clathrin-mediated trafficking, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y6Q5; product specifications from Assay Genie datasheets.