FAM3A
FAM3A (FAM3 metabolism regulating signalling molecule A) is a secreted, cytokine-like protein of the FAM3 family, also known as DXS560S, 2-19 and XAP-7. It may contribute to antifungal defence and to the regulation of glucose and lipid metabolism. Browse Assay Genie's current range of FAM3A research reagents below, or read on for the biology behind the target.
FAM3A is a secreted protein that belongs to the FAM3 family. UniProt annotates it as a protein that may act as a defensin against invading fungal microorganisms, which points to a possible role in host defence. The NCBI Gene summary describes the gene as encoding a cytokine-like protein, and suggests that the encoded protein may be involved in the regulation of glucose and lipid metabolism.
The expression of the FAM3A gene may be regulated by peroxisome proliferator-activated receptor gamma (PPAR gamma), a link that places the protein within metabolic signalling networks. Alternative splicing of the gene results in multiple transcript variants. The human protein is catalogued as UniProt P98173, and the mouse ortholog is Fam3a, which allows comparative work in rodent models.
The gene has carried several names. HGNC lists the previous name as family with sequence similarity 3 member A, and the aliases DXS560S, 2-19 and XAP-7 still appear in older literature and databases. The current HGNC name, FAM3 metabolism regulating signalling molecule A, reflects the metabolic function proposed for the protein. Researchers studying FAM3A often consider it alongside the other FAM3 family members, since the family shares a common designation and a cytokine-like character.
FAM3A may be involved in the regulation of glucose and lipid metabolism, making it a candidate for studies of metabolic signalling.
Expression of FAM3A may be regulated by peroxisome proliferator-activated receptor gamma, linking the protein to nuclear receptor pathways.
UniProt proposes that FAM3A may act as a defensin against invading fungal microorganisms, which supports investigation of innate defence.
As a secreted, cytokine-like protein of the FAM3 family, FAM3A is relevant to comparative studies of this family's signalling functions.
FAM3A is a secreted, cytokine-like protein. UniProt notes it may act as a defensin against invading fungal microorganisms, while the NCBI Gene summary suggests it may be involved in regulating glucose and lipid metabolism. Both roles are described cautiously, as the source annotations use the word 'may'.
HGNC gives the full name as FAM3 metabolism regulating signalling molecule A, with the previous name family with sequence similarity 3 member A. Aliases and previous symbols include DXS560S, 2-19 and XAP-7. UniProt uses the name Protein FAM3A. Alternative splicing produces multiple transcript variants.
A mouse ortholog, Fam3a, is recorded for the human gene. FAM3A is one member of the FAM3 family, which also includes FAM3B, FAM3C and FAM3D. Check the datasheet of any product for its validated reactivity.
Other FAM3 family members and further FAM-designated proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P98173; product specifications from Assay Genie datasheets.